Medicine – Page 7 – Force Health Care

Treating Pcos With Acupuncture And Chinese Medicine

Posted on January 12, 2019 by admin

For many women, losing weight is a never-ending struggle. No matter how hard they try, the pounds just won’t come off. All the dieting and endless hours in the gym leave them feeling fatigued, hungry and infinitely frustrated with lack of progress. Well, guess what? It might not be your fault. You may have a hormonal condition call Polycystic Ovarian Syndrome (PCOS), making it all but impossible to lose the weight you want to lose. There are many possible symptoms for PCOS and treatment options are available from both Eastern and Western medicine. Western treatments involve different types of hormone therapy, while Eastern treatments rely on acupuncture and herbal therapy.

Women with PCOS develop numerous cysts on their ovaries, which is how it gets its name. Other signs and symptoms include weight gain (very often in the abdomen), obesity, excessive hair growth on the face, thinning hair on the scalp, acne and irregular periods. For women, with PCOS, who exercise rigorously, the weight in the belly just never seems to go away and is a constant source of frustration for them. Very often women with PCOS will have delayed cycles or even miss a period completely and when the period comes, it is usually quite painful. This disruption in the cycle also makes it very difficult for women with PCOS to get pregnant. In fact, PCOS is one of the leading causes of infertility in women, yet many women don’t even know they have it. Many of these symptoms can be associated with a high level of testosterone, which women with PCOS have. Chinese Medicine can help to balance the body, regulate the natural cycle and restore ovulation.

While Western medicine looks at illness in a linear way, Eastern Medicine takes a holistic approach. What this means is that having a specific illness doesn’t necessarily mean that everyone gets the same treatment. We treat the root cause of the problem and not just the symptoms. In Traditional Oriental medicine, PCOS can be attributed to three different diagnoses. A patient may have one, a combination of two or all three syndromes (having all three is the most common). These three diagnoses are: Accumulation of Phlegm and/or Damp, Kidney Yang deficiency and Stagnation of Qi and/or Blood. If the patient has all three going on, one of the syndromes is usually predominant, but all three need to be addressed. Acupuncture treatments to resolve phlegm and damp, move Qi and Blood, and Tonify Kidney Yang are used, along with Chinese herbal formulas. Studies have shown that electro-acupuncture treatments are the most effective for patients with PCOS. The low electrical current (machines are run on 9-volt batteries) can help lower testosterone levels.

Women with PCOS should take this condition very seriously. Besides the obvious physical signs, PCOS can lead to some even more serious conditions such as diabetes, obesity, stroke and cardiovascular disease. A treatment plan involving acupuncture, natural Chinese herbs and a regular exercise routine can keep your hormone levels in check and help you avoid going on hormone therapy.

Buy cheap prescription medicine online

Posted on January 11, 2019 by admin

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Online medicine-My Care Pharmacy

Posted on January 10, 2019 by admin

Refers to multiple online pharmacy crime continue to rise and the public is clamoring for the purchase proactive efforts by the Boards of the drug and the number of nations. Even the different authorities in different societies around the world are joining hands to participate in the question of the proliferation of online shops.

All users are suggestive of the World Wide Web to be much more careful after a pharmacy online. Although many people are dependent on the decisions of the positive, a large numbers of joint action in the selection of good many bad. Other groups are also stepping up and choosing a critical attitude towards the authorities pro in action.

For example, a provider of web services monitoring LegitScript.com pharmacy has reported on the lack of key U.S. Drug Enforcement Administration Action on Internet pharmacies that sell drugs without suspicion dependence on statute of limitations requirements.

The report examines the application of DEA height of Consumer Protection online Ryan Pharmacy Act 2009, a law called an age of 18 who died just after an overdose of Vicodin and Xanax, which had been purchased in web without legitimate prescription from a doctor.

The law is intended to give battle to curb illegal DEA teeth online marketing pharmaceuticals, but the latest research shows that the Agency is not yet on file with the new law. The review also cites studies DEA chief in October 2010 as saying that “the Internet is not as big a problem as all of us thinking … what to do with controlled substances” added that they were able to reveal the possible sale of drugs counterfeit.

The study is at odds with the claims of the DEA and the product to identify about 1,000 rogue pharmacies Web Wide World actively marketing and advertising and sale of controlled substances to U.S. residents. Most web pages are on American soil based on a screenplay by Legit.

In fact, to find a legitimate online pharmacy is like the proverbial needle-in-the-haystack hunt. Number of web stores that offer less expensive items shady continues to grow at the same time. Drugs are not tested very easily and erroneously and even the slopes of the Internet customers include many of the self-care problems as well as citizens and governments through the agencies that regulate the pharmaceutical industry. Most sites take advantage of this inclination wrong buyer, and thus provide a cost-effective drugs, which were the date of expiry of counterfeit false or misleading.

Do not make the mistake of legal online pharmacies, after all, offers even more advantages. Patrons of a network of drug stores to say what incredibly low fares do not really make a difference to the comfort of the medication ordered a few mouse clicks.

Easy to find data associated with drugs may also offer another advantage over most online pharmacies offer. Most online pharmacies often genuine article formulations, disadvantages, indications, and other relevant characteristics often printed inside the packaging.

Get trusted with my care pharmacy that is very valuable today as the authorities have yet to show the actions defined in the closure of dubious online pharmacies. Meanwhile, pick a store that follows the laws of world and local rules. Stay away from becoming a victim of widespread Internet scams by learning methods that operate illegally. Jennifer is the author work with the My Care Pharmacy that is a fantastic online pharmacy store. It is the best facility for the users of World Wide Web to Buy Medicine online with a perfect home delivery. For further information must visit http://www.mycarepharmacy.com/

How Natural Medicine Can Help You

Posted on January 9, 2019 by admin

When you get sick, you go to the doctor. And the doctor will, of course, prescribe medicines. You will go and buy medicines. You take them, and hopefully, you get well.

This is how the health profession goes on nowadays – a cycle of diagnosis and prescription.

If anyone were to give you herbs for medicine, you would probably say that that person was a quack.

But nowadays, studies are being conducted to see if there are really is any merit to what is called natural medicine.

Natural medicine is the use of natural methods, herbal medicines, and traditional practices to heal ailments. Every culture has a form of natural medicine. In ancient cultures, village medicine men served as the doctors of the community, passing on medical knowledge to the apprentices that followed them.

Many categories of the healing methods fall under natural medicine. Among these are traditional medicine, complementary medicine, and alternative medicine.

Usually, natural medicine refers to medical practices that were in place before the advent of modern medicine.

This includes herbal medicine, or phytotherapy, which is prevalent in Chinese, Ayurvedic(or Indian), and Greek medicine.

Upon the advent of modern medicine, many professionals discarded the use of herbs in favor of man-made medicine. The fact that these treatments are based on the healing properties of some herbs was forgotten.

For example, opium, digitalis, quinine, and aspirin all have their roots in traditional medicine.

Natural medicine can be considered as a lost art. This does not mean that it has lost efficacy over time. In some cases, natural therapy is actually better than modern medicine. This leads some doctors to seriously consider and study the possible uses of natural medicine

Before we continue, it is important to stress that not all the natural remedies are legitimate. It would help to only try those remedies which have been thoroughly studied and are relatively risk free.

Take herbal medicine for example. There are many well-documented and studied herbal remedies available. However, only those that deal with minor ailments such as cough, colds, fever, skin rashes, and its ilk are likely to be recommended by health professionals. These remedies are sometimes superior to synthetic medicine. This is because herbal medicines are less likely to cause negative side effects.

Currently there are numerous organizations that study the effects and advocacy of natural medicine – among which is herbal medicine. Some governments and health agencies openly advocate the use of natural methods since they are inexpensive and relatively risk-free.

As their studies compile, more herbs and treatments are added to the list of accepted medicines. However, many herbs and treatments have been proven to be bogus medicine. This represents a challenge for both the user and the agencies because they have to ascertain that the treatments they either use or advocate are legitimate.

There exist today many alternative medical treatments that fall under natural medicine. However, not all of them have been proven to be effective. You could mention homeopathy, aromatherapy, acupuncture, and other alternative medical treatments. It would pay to consult the experts as to the legitimacy of these treatments.

Natural medicine should also be thought of as an accompanying medicine. Right now, the current collective medical thought suggests that natural medicine be used only to supplement accepted modern medical practices. In that case of minor ailments your expert we actually advise you to take natural therapies instead.

The practice of modern medicine revolves around diagnosing an illness and prescribing treatments for such. Natural medicine is helpful because it suggests that treatment be not necessarily given only when sick. Natural medicine strives to make each patient practice good health habits. These habits include good diet, healthy living, and the regular natural treatment.

It is this same line of thought that leads our parents to tell us to eat our vegetables. Yes, a healthy lifestyle and will do no harm to our well-being. And this is the foundation of natural medicine – may it be massage, herbal medicine, aromatherapy or others.

It is funny but true that science, in its quest for excellence, is studying the knowledge of sages past. This, surprisingly, leads us back to the remedies nature offers. The possibilities of finding remedies to everyday illnesses in natural medicine are encouraging. So staying tuned to studying these remedies is worthwhile until we can verify that these therapies are truly helpful to our health and our society.

Additional reading is available on eczema treatment.

Electron Ionization Cross Section in relation to dosage of medicine-Antimicrobial drugs

Posted on January 5, 2019 by admin

Electron Ionization Cross Section in relation to dosage of medicine-Antimicrobial drugs By (1 S.Kavitha, 2 V.R. Murthy,,3 K.R.S. Samba Siva Rao)1(Research Scholar, Dept. of Biotechnology, Acharya Nagarjuna University, Guntur. Andhra Pradesh. India, 2(Prof.& Head, Dept. of Physics (P.G. Course), T.J.P.S. College, Guntur. Andhra Pradesh. India. (3 Prof. & Head, Dept. of Biotechnology, Acharya Nagarjuna University, Guntur. Andhra Pradesh. S.,*Corresponding author

Abstract

Physical parameters such as molecular polarizability, diamagnetic susceptibility, and molecular electron ionisation cross section are important parameters bearing some dependence on the dosage of the medicine through the electron transfer of the medicine in the process of diagnosis. Hence they are analysed and used in calculating the dosage of few anti-microbial drugs, in particular Quinolones. Data collected on Plasma protein binding Bioavailability, Half-life period and Log P show dependence on Q and is expressed in the form of a mathematical equation. The dosage thus calculated by above parameters has a good agreement with the suggested dosage values. For example Ciprofloxacin has the reported dosage value1.0grms/day against the calculated dosage value 0.849grams /day. In case of other drug Lomefloxacin, the calculated value is 0.394 grams /day against the reported value 0.4 grams /day. Similar observation was done in case of other quinolones compounds also. The present method enables a new approach in finding out the drug activity and is preferred to the highly theoretical approaches involving quantum mechanical methods.

Key words: Dosage, Half Life Period, Electron Ionisation cross section.

Introduction: The quinolones are potent synthetic chemotherapeutic, broad-spectrum antibiotics 1, 2. Since the introduction of Nalidixic acid in 1962 3, 4 several structural modifications have resulted in second, third and fourth generation antibiotics. With the recent introduction of agents such as Gatifloxacin and Moxifloxacin, the traditional gram-negative coverage of fluroquinolones has been expanded to include specific gram positive organisms5.Community acquired pneumonia is the sixth leading cause of death in the United States. Even with optimal therapy, this illness is associated with mortality rates of approximately 15 percent.6

Therapeutic uses of fluoroquinolones include the following: 1) For serious acute cases of pyelonephritis or bacterial prostatis, where the patient may need to be hospitalised, fluoroquinolones such as Ciprofloxacin, 7oflaxacin, lomefloxacin, enofloxacin, levofloxacin and gatifloxacin are recommended.8 2) Due to excellent penetration into prostatic tissue, norfloxacin, levofloxacin,ciprofloxacin and iflaxacinhave eradication rates of 67 to 91%.9,7 3) The U.S.Food and drug administrationhas labelled gatifloxacin, moxifloxacin, sparfloxacin and levofloxacin for use in the treatment of acute sinusitis.10For severe forms of community aqured pneumonia , the fluroquinolones are associated with improved treatment rates.11 4) In case of sexually transmitted diseases, a single dose of ciprofloxacin or ofloxacin is considered as alternative treatment in for example patients with pencillin allergy.12 5) Fluroquinolones in combination with other drugs such as ofloxacin plus metronidazole or Cefoxitin and ciprofloxacin plus clindamycin 7,10 are used to relieve pelvic inflammatory, Diabetic food infections etc. Norfloxacin or ciprofloxacin are used in the treatment of traveller’s diarrhea and certain other infections such as typhoid fever and Vibrio cholera. Adverse events: Although quinolones are well tolerated and relatively safe, certain adverse effects are 13, 14 common. Gastro intestinal and Central nervous system 15,16 effects are the most frequent adverse events occurring in 2 to 20 per cent of patients 17-22.Other adverse effects such as QTC prolongation, 23,24 hepatotoxicity, tendon rupture, cardiovascular toxicity, disturbed blood glucose levels 25,26 certain dermatologic effects etc.

Mechanism of fluoroquinolones: Fluoroquinolones interfere with bacterial DNA metabolism by the inhibition of two enzymes, Topoisomerase II (Syn. DNA gyrase) and Topoisomerase IV. In gram-negative organisms DNA gyrase is the primary target, where as in Gram -positive bacteria topoisomerase IV was recently found to be most affected. The function of DNA gyrase is to introduce supercoils into the linear DNA double helix, which results in the highly condensed three dimensional structure of the DNA usually present inside the cell. The function of topoisomerase IV is involved in the separation process of the DNA daughter chains after chromosome duplication. DNA gyrase and Topoisomerase IV have a very similar protein structure, each composed of two sub units(Gyr-A and gyr-B). The Gyr-A subunits of this enzyme were proposed to initially bind to the double stranded DNA helix. In an ATP-dependent process, described as intermediate gate opening step-, both DNA strands are leaved at certain 4 base pair staggered sites. The 5’ends of the DNA chain are thereby bound covalently to Tyrosine 122 residues with in the Gyr-A-subunits. Gyr-B-subunits are probably responsible for the ATP-dependent releasing process of the DNA. Two quinolones molecules self-assemble inside the pocket in dimer structure 27 and attach to the gyrase -DNA complex electrostatically, which stabilizes the intermediate stage of this reaction step. Permanent gaps in the DNA strands induce synthesis of repair enzymes (exonucleases) initiating uncoordinated repair process, which results in irreversible damage to the DNA and, finally, cell death. 28, 29

Methodology: A knowledge of Molecular polarizability, diamagnetic susceptibility, Molecular electron ionisation cross section reflects on transport mobility, activity and the vigour of the electron associate with the interaction of the medicine with the electrons released from host cell(or effected cell) of the body during the reaction .Hence an investigation of these properties leading to the dosage of the few anti-microbial drugs (Quinolones) is taken up in the present investigation. The above parameters are obtained through quantum mechanical approach of Lippincott, Bond Polorizability and Bond Refractivity of Le Fevre. The diamagnetic susceptibility for these systems is evaluated using Rao &Murthy’s method. The molecular electron ionization cross section is then evaluated from diamagnetic susceptibility using modified Kevan’s formula of Murthy et al. The electron ionization cross section along with the data of Protein binding, Bioavailability, Log P,& Half-life are taken from Wikipedia are used in the present investigation.30 The related work of drug dosage activity through molecular electron ionization cross- section and medical parameters like bioavailability, protein binding etc., has been reported by Murthy et al in a few medicinal systems. 31, 32, 33 The present paper deals with the evaluation of dosages of a few anti-microbial drugs (Quinolones). The information regarding the Molecular polarizability obtained by Lippincott method, Bond polarizability and Bond refractivity, diamagnetic susceptibility and molecular electron ionisation cross section was given in already accepted previous papers31, 32, 33, 34

?aP = 4nA/ao [(R2/4) + (1/2(CR)2)]2 x e-(XA-XB)2/4 (1)

?an = ? fj aj (2)

? 2 a- = n df ?2j/?j2 (3)

aM=1/3[?aP+? a n +? 2 a-] (4)

aM=?[3/4pN?](R8) (5)

aM= n1 a(c=c) + n2 a(c-c) +———– ——–=Ojnjaj (6)

?M = ? m s1aM (7)

Q (in 10-16cm2)=0.278n ?M ( 8)

Molecular polarizablility can be calculated by Lippincott method, Bond refraction method and Bond polarizability method. The aM by Lippincott method is evaluated with help of parallel component (?a?p), Perpendicular component (?2a-) and ?a?n .The parallel Component?a?p, is based on parameters i.e. A, CR, ao are taken from Lippincott35 are given in the equation(1).The values of bond lengths required for evaluating?a?p are taken from CRC Hand book of Physics and Chemistry.36 Similarly the perpendicular component is given in the equation(3).The electronegativity and atomic polarizability values are taken from the reference.36Thus calculated ?a?p, ?a?n and ?2a- are given in table I. Finally from these values aM is measured by the formula (4). Molecular polarizabilty obtained by other methods i.e Bond polarizablity and Bond refraction methods are given table II. The values needed to calculate the mean molecular polarizabilty -aM’ from Bond refractivities and Bond polarizabiltes are taken from Le Fevre37.and expressed in 10-25cm3.

The diamagnetic susceptibility -?M’ is calculated with the help of equation 7. The -aM’ values obtained by three methods i.e. Lippincott, Bond polarizablity and Bond refraction are inserted in the given equation which gives the ?M. The necessary data required for the calculation of -s’ Covalency factor taken from reference. 38

The covalency factor is calculated as s=[s1 1/n1. s2 1/n2——–s n 1/n8-]1/2 (9) s=e-(XA-XB)2/4 Where XA and XB are electronegativity of the bond A- B respectively and n1, n2 are the bond orders. Calculation of ?M is immediately followed by -Q’, Electron ionisation cross section which only needs the ?M value. The ?M and -Q’ values obtained by Lippincott Bond polarizablity and Bond refraction are shown in the table III. Practical approach for diamagnetic susceptibility through vibrational magnetometer technique is under progress. Of the three methods -Q’ obtained by Bond polarizablities are taken as standard because, this method is found to be sensitive to conformational changes than the other two methods. In table IV, the calculated values of Electron ionisation cross section -Q’ along with other medicinal parameters are given. These include Protein binding, Bioavailability, Log P and Half life period of some anti-microbial (Quinolones). The data required are taken from Wikepedia30. By calculating the -Q’, an attempt has been done in studying the activity of a drug and further its interaction with the target molecule. Finally with the help of the expression 10, dosage of antimicrobial drugs is calculated and compared with the reported dosage values taken from reference 30. The results are given in the table V.

=((Q/D)2/3LLogP) va/5 (10)

Where, Q – Electron ionisation cross section D-Dosage of the drug L- is the Half-life period Log P -Hydrophobicity a= (PB)(BA)/6ms

Where, m – the no.of unsaturation bonds PB -Protein binding BA-Bioavailabilty s- the Covalency factor

Results and Discussion: A keen observation of the dosages of the medicinal compounds calculated and reported show he following features. The calculated dosage of Prefloxacin is 0.825 grams per day against the reported dosage value 0.8grams per day. Similarly Lomefloxacin and Sparfloxacin has the calculated value 0.394 grams per day and 0.211 grams per day compared with the reported dosage value0.4 grams and 0.222grams per day. Good agreement regarding the dosage values were observed in case of other medicinal compounds also. An analytical approach on Q and medicinal parameters reveal some observations .Generally the medicinal compounds having similarity in their structure are analysed. In case of Quinolones (Antimicrobial drugs) ,Prefloxacin has the -Q’valuei.e3.03×10-16 cm2 less than Lomefloxacin Q value11. 27×10-16 cm2 But increased half-life period 8.6hrs than half life period of Lomefloxacin 3 to 5 hrs. Similarly for Nalidixic acid the half life is 1.1to2.5hrsless than the Ciprofloxacin h alflife period i.e.3 to 4 hrs. Compared to the -Q’ values of Nalidixic acid (12.23×10-16 cm2) and Norfloxacin (8.33×10-16 cm2). An attempt has been made in analysing the relation between Log P (Hydrophobicity) and ‘Q’ Electron ionization cross section. The hydrophobicity of Sparfloxacin is2.5 compared with the hydrophobicity value of Moxifloxcin 2.9 against the -Q’ value Sparfloxacin11.806×10-16 cm2 and Moxifloxacin 9.459 x10-16 cm2. Similar observations is done in case of Prefloxacin and Lomefloxacin. From the above data it is hypothesized that lower the hydrophobic nature of the drug higher may be the interaction of the drug with the target molecule and finally the activity of drug molecule i.e. Electron ionization cross section. Comparison of -Q’, Electron ionisation cross section value and the dosage value reflect some useful and supporting view to the above analysis. In case of Sparfloxacin Q value ( 11.806×10-16 cm2). The reported dosage value is0.22grams per day againt the lower Moxifloxacin Q value 9.459 x10-16 cm2 and higher dosage value 0.4grams per day respectively. Similarly Lomefloxacin (Q value11. 27×10-16 cm2) has 0.4grmas per day to Prefloxacin (Q’valueless than Lomefloxacin i.e3.03×10-16 cm2) dosage value 0.8 grams per day. Rigorous work is under study in order to understand the relation between -Q’, dosage and other medicinal parameters of other medicinal compounds.

A plausible explanation for this behaviour may be given as follows. An increase in electron transportation activity reflected by higher electron ionization cross section will tender the chemical reaction to be faster. Hence an incidence of electron from the donor to the place of malignity will make the process curing faster. Thus very little dosage of the medicine will be sufficient. A long continued impingement of the electrons on the malgn cells might develop saturation effects. Hence the life time of the drug for limited time suggested. Thus an increase in Q explains lower half life and lower dosage. A continued dosage of such medicine might result in undesirable toxic effects. Rigorous work is under study in order to understand the relation between -Q’, dosage and other medicinal parameters of other medicinal compounds.

Inference: The present method hints at study of important physical parameters like refractivity and electron ionization cross section through simple molecular structure. An elucidation of Q and its use with other medicinal parameters yield a new method of obtaining medicinal dosage. Thus the present method of arriving at medicinal dosage through physical parameters n, k ,Q give a novel approach of equation of dosage and looking at it from molecular level of interactions. This approach has the superiority over the already available sophisticated medicinal methods which involve highly theoretical quantum mechanical modelling, highly computive modelling or highly sophisticated physicochemical methods of drug analysis.

References 1)Nelson JM, Chiller TM, Powers JH, Angulo FJ (April 2007). “Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story”. Clin. Infect. Dis. 44 (7): 977-80. doi:10.1086/512369. PMID 17342653. http://www.journals.uchicago.edu/doi/abs/10.1086/512369?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov 2)Ivanov DV, Budanov SV (2006). “[Ciprofloxacin and antibacterial therapy of respiratory tract infections]” (in Russian). Antibiot. Khimioter. 51 (5): 29-37. PMID 17310788 3)Stacy J. Childs, MD (2000). “Safety of the Fluoroquinolone Antibiotics: Focus on Molecular Structure”. Infect Urol (USA: FQresearch) 13 (1): 3-10. 4)Catherine M.Oliphant,Pharm.D.,Gray M. Green, M.D.,-Quinolones: A Comprehensive Review-,Am Fam Physician. 2002 Feb1;65(3):455-465. 5)Turnidge J. Pharmacokinetics and pharmacodynamics of fluoroquinolones. Drugs. 1999;58(suppl 2):29-36. 6)Bartlett JG, Dowell SF, Mandell LA, File TM Jr, Musher DM, Fine MJ. Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Disease Society of America. Clin Infect Dis. 2000;31:347-82. 7) Hooper D. Quinolones. In: Mandell GL, Bennett JE, Dolin R. Mandell, Douglas, and Bennett’s Principles and practice of infectious diseases. 5thed. Philadelphia: Churchill Livingstone, 2000:404-23. 8)Liu, H.; Mulholland, SG. (July 2005). “Appropriate antibiotic treatment of genitourinary infections in hospitalized patients.”. Am J Med 118 Suppl 7A: 14S-20S. doi:10.1016/j.amjmed.2005.05.009. PMID 15993673. 9)Sabbaj J, Hoagland VL, Cook T. Norfloxacin versus co-trimoxazole in the treatment of recurring urinary tract infections in men. Scand J Infect Dis 28 Suppl. 1986;48:48-53. 10)Hooper DC. New uses for new and old quinolones and the challenge of resistance. Clin Infect Dis. 2000;30:243-54. 11)Vardakas, KZ.; Siempos, II.; Grammatikos, A.; Athanassa, Z.; Korbila, IP.; Falagas, ME. (December 2008). “Respiratory fluoroquinolones for the treatment of community-acquired pneumonia: a meta-analysis of randomized controlled trials.”. CMAJ 179 (12): 1269-77. doi:10.1503/cmaj.080358. PMID 19047608. PMC 2585120. http://www.cmaj.ca/cgi/content/full/179/12/1269 12)1998 guidelines for treatment of sexually transmitted diseases. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep. 1998;47(RR-1):1-111. 13)De Sarro A, De Sarro G (March 2001). “Adverse reactions to fluoroquinolones. an overview on mechanistic aspects” (PDF). Curr. Med. Chem. 8 (4): 371-84. PMID 11172695. http://www.fqresearch.org/pdf_files/cmc.pdf. 14)Owens RC, Ambrose PG (July 2005). “Antimicrobial safety: focus on fluoroquinolones”. Clin. Infect. Dis. 41 Suppl 2: S144-57. doi:10.1086/428055. PMID 15942881. 15)Owens RC, Ambrose PG (July 2005). “Antimicrobial safety: focus on fluoroquinolones”. Clin. Infect. Dis. 41 Suppl 2: S144-57. doi:10.1086/428055. PMID 15942881. http://www.journals.uchicago.edu/cgi-bin/resolve?CID34940

16) Iannini PB (June 2007). “The safety profile of moxifloxacin and other fluoroquinolones in special patient populations”. Curr Med Res Opin 23 (6): 1403-13. doi:10.1185/030079907X188099. PMID 17559736. 17)Hooper DC. Mode of action of fluoroquinolones. Drugs. 1999;58(suppl 2):6-10. 18)Hackbarth CJ, Chambers HF, Sande MA. Serumbactericidal activity of rifampin in combination with other antimicrobial agents againstStaphylococcus aureus. Antimicrob Agents Chemother. 1986;29:611-3. 19)Walker RC. The fluoroquinolones. Mayo Clin Proc. 1999;74:1030-7. 20). Lipsky BA, Baker CA. Fluoroquinolone toxicity profiles: a review focusing on newer agents. Clin Infect Dis. 1999;28:352-64. 21)Stahlmann R, Lode H. Toxicity of quinolones. Drugs. 1999;58(suppl 2):37-42. 22)Harrell RM. Fluoroquinolone-induced tendinopathy: what do we know?. South Med J. 1999;92:622-5. 23)Falagas ME, Rafailidis PI, Rosmarakis ES (April 2007). “Arrhythmias associated with fluoroquinolone therapy”. Int. J. Antimicrob. Agents 29 (4): 374-9. doi:10.1016/j.ijantimicag.2006.11.011. PMID 17241772. 24)Rubinstein E (2001). “History of quinolones and their side effects”. Chemotherapy 47 Suppl 3: 3-8; discussion 44-8. doi:10.1159/000057838. PMID 11549783. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=che7c003 25)Mehlhorn AJ, Brown DA (November 2007). “Safety concerns with fluoroquinolones”. Ann Pharmacother 41 (11): 1859-66. doi:10.1345/aph.1K347. PMID 17911203. 26)Lewis RJ, Mohr JF (2008). “Dysglycaemias and fluoroquinolones”. Drug Saf 31 (4): 283-92. doi:10.2165/00002018-200831040-00002. PMID 18366239. 27)Hooper DC, Wolfson JS: Mechanism of quinolone action and bacterial killing, in Hooper DC, Wolfson JS (eds): Quinolone Antimicrobial Agents, ed 2. Washington DC, American Society for Microbiology: 53 – 75, 1993. 28)Shen LL: Quinolone – DNA interaction, in Hooper DC, Wolfson JS (eds): Quinolone Antimicrobial Agents, ed 2. Washington DC, American Society for Microbiology: 77 – 95, 1993. 29)Morais Cabral JH, Jackson AP, Smith CV, Shikotra N, Maxwell A, Liddington RC: Crystal structure of the breakage-reunion domain of DNA gyrase. Nature Vol 388 / 28: 903 – 906, 1997. 30)http://www.winkipedia.com 31)Murthy, V.R.& Venkata Raghuram D, Drug, dosage, activity, Studies of antimalarials by Physical methods-II, Bonformation 2(1); 12-16(2007). 32)Murthy, V.R.& Venkata Raghuram D and Murthy, P.N.romanian J.Phy. 17, 207, 2007. 33)Murthy, V.R.& Venkata Raghuram D and Murthy, P.N. Proce.National Seminar recent trends in Biomedical Physics. Guntur.(India) p.122-132. 34)V.R. Murthy, S.Kavitha, K.R.S. Samba Siva Rao,- Drug, Dosage Studies of A Few Centrally Acting Muscle Relaxants- http://www.amazines.com/article_detail.cfm?articleid=2205851. 35) Rao. B.P., Murthy,V.R.,-Curr.Sci.-,1972, 41, No:1

36) David, R. Lide, CRC Hand Book of Chemistry and Physics, National Institute of Standard Technology, CRC Press LLC, London, (2004). 37)Molecular Refractivity and Polarizability by R.J.W. Le Fevr, Advances in Physical Organic Chemistry 3,1-90,(1965). 38) A Hand Book Of Chemistry and Physics ,CNR Rao, Mahanthy & others, Affliated East &West Press Limited, New Delhi,(1967).

TABLE-1 Molecular Polarizabilities of Anti-microbial drugs(Quinolones) by Lippincott method in 10-25cm3

S.NoName of the drug?a?p?a?n?2a- 1Nalidixic acid469.19117.784231.208 2Norfloxacin645.04924.96346.985 3Ciprofloxacin691.86624.956272.072 4Sparfloxacin768.94024.956272.072 5Moxifloxacin862.9924.703329.746 6Prefloxacin680.24320.756306.652 7Lomefloxacin687.93520.756269.383

TABLE-II Molecular Polarozablities (aM) in 10-25cm3 S. NoName of the drugaM by Lippincott methodaM by Bond PolarizablityaM by Bond Refraction 1Nalidixic acid231.208266.244247.319 2Norfloxacin315.907346.985333.101 3Ciprofloxacin329.631366.252342.97 4Sparfloxacin385.709383.183378.339 5Moxifloxacin405.814423.115421.671 6Prefloxacin335.894354.352352.635 7Lomefloxacin326.025347.852347.166

TABLE-III The Diamagnetic Susceptibilities (in 106CGS units) and Molecular Electron Ionisation cross section (in10-16cm2)of certain Anti-microbial drugs(Quinolones) ? M in 106CGS units Qin10-16cm2 S.NoName of the drugByByByByByBy LippincottBond PolarizabilityBondLippincottBond PolarizabilityBond Refraction method Refractionmethod 1Nalidixic acid56.41764.96760.3411.43313.16612.23 2Norfloxacin38.98942.82541.1127.9028.6798.332 3Ciprofloxacin65.82373.14668.49512.3414.82413.881 4Sparfloxacin59.39959.10158.25612.03811.97811.806 5Moxifloxacin44.9246.83546.6779.1049.4929.46 6Prefloxacin14.25415.03814.9642.8893.0483.033 7Lomefloxacin53.85155.74855.63810.91411.29511.276

TABLE-IV Electron Ionisation cross section (in10-16cm2 ) and other medicinal parameters

S.NoName of the drugQ PB BALog PHalf Life(hrs) 1Nalidixic acid12.23093962.11.1-2.51.383 2Norfloxacin8.33215502.13-41.1383 3Ciprofloxacin13.88130502.53-51.176 4Sparfloxacin11.80650502.5201.272 5Moxifloxacin9.45986-92402.9121.477 6Prefloxacin3.033251002.48.61.450 7Lomefloxacin11.2760.725502.13-51.335

TABLE-V Drug dosage (in grams/day) S. NoName of the druga’Calculated dosages grams/dayReported dosages grams/day 1Nalidixic acid0.0951.3834.0334.0 2Norfloxacin0.0091.1380.6510.80 3Ciprofloxacin0.0131.1790.8491.0 4Sparfloxacin0.0261.2730.2110.222 5Moxifloxacin0.0491.4750.4090.40 6Prefloxacin0.0691.4490.8250.8 7Lomefloxacin0.0371.3350.3940.4

Preventive Medicine Can Reduce the Risk of Cardiovascular Disease

Posted on January 4, 2019 by admin

Preventive medicine is a specialized medical field that is aimed at preventing disease and promoting health. These doctors use their expertise for health issues that cause a major impact on certain populations. One such problem that these doctors specialize in is cardiovascular disease. This condition affects millions of people around the globe and is the leading cause of death in many countries, including the United States. Oftentimes, those who do suffer from this problem have several risk factors that with preventive medicine could be reduced or managed. These doctors help to reduce the factors in preventing these diseases as well as help those who do have cardiovascular problems by providing services and education for healthier heart living.

Risk Factors for Cardiovascular Disease Extensive studies have been conducted for identifying specific major risk factors for cardiovascular disorders. Some of these cannot be changed, while others can. Individuals who have more of these risk factors, have a greater chance of developing heart disease. Major contributing factors that cannot be changed include aging, being male and genetic predisposition. Among major factors that can lead to cardiovascular conditions and can be changed include smoking, high cholesterol, physical inactivity, high blood pressure, diabetes mellitus, obesity or being overweight. Stress and consuming too much alcohol may also lead to heart problems.

Preventive Medicine and Cardiovascular Disease When visiting a doctor of preventive medicine in Kentucky for help to reduce the chance of developing cardiac disorders or for managing these conditions, the physician will do a risk assessment, which may include a stress test, advanced cholesterol tests and other testing to determine the condition of the cardiovascular system and what measures can be taken to prevent this deadly disease. Treatments may include a special diet, changes in lifestyle, medical nutrition therapy, nutriceuticals, phytochemicals, an exercise program, a smoking cessation program, expert cholesterol control and management, diabetes prevention and weight management. The treatment regime may also include vitamin therapy as well as certain supplements such as fish oil.

Educating Patients Education is a major role of preventive medicine physicians. Some offer specialized programs for optimal reduction of the risks of heart diseases, which may include a cardio-exercise program for individuals who are obese or overweight or those who have heart conditions. Other specialty programs may be directed at patients with diabetes or pre-diabetes, patients with a family history of diabetes or heart problems or those with high triglycerides and cholesterol. Programs usually include education about the causes of these conditions as well as benefits of exercising, changing lifestyle and diet. Medications, supplements, vitamins and phytochemicals are also discussed in regards to how they reduce the chances of developing cardiac disease.

Remote Medicine

Posted on January 4, 2019 by admin

Telemedicine or remote medicine is one aspect in medical technology that has been steadily developing in the recent times. Remote medicine can be defined as experts assisting patients’ treatments in remote areas by using high-end telecommunication systems. Sometimes physicians have to perform surgeries on patients using robotic arms through these high-end telecommunication systems. Doctors in remote areas can purchase emergency medical supplies and first aid kits required for remote medicine treatment from popular online stores.es.

Many surgeries have been performed successfully through remote medicine. Sometimes it is neither practical nor financially feasible for the sick or injured to travel to developed nations for their medical treatment. Thanks to remote medicine, people in remote areas can get treatment from experts without having to travel. Although it is useful in many ways to patients across the globe, it could be difficult in certain cases given access, supplies and knowledge of local professionals. There are some doctors who believe another barrier is the difficulty in building a bond between doctors and patients because of the virtual communication.

However, with lack of specialists in intensive care units in many rural areas across the globe, remote medicine provides a helping hand in monitoring and treating critical patients. Remote medical technology is only as good as the supplies on hand. Putting this technology into practice requires people in remote areas to have relevant emergency medical kits and emergency medical supplies to treat patients.

Chinook Medical Gear is a very popular online store that offers a wide range of emergency medical supplies, medical kits, first aid kits, and containers that are specifically designed to be used in remote areas during emergency situations. This online store also ships emergency medical supplies to remote places for assisting field doctors in those areas. People involved in remote medical treatment can now be assured that they will receive well-stocked first aid kits as fast as possible from this online store.

How Does Traditional Chinese Medicine Inhibit Tumor Recurrence And Metastasis

Posted on December 28, 2018 by admin

Some tumour has an aggressive clinical course, with a high tendency for both local recurrence and distant metastasis. Relapse and metastasis are the main causes responsible for failure of surgical operation in treating malignant tumors. Inhibition of tumor recurrence and metastasis is a very important thing during cancer treatment. Hence harmonizing the dynamic balance between yin and yang and maintaining the homeostasis of internal environment is the vital treatment principle of tumor. This made TCM Oncology become an indispensable role in the system of cancer prevention and treatment.

Cancer, the medical term that cancer, in medicine, said rock, ground control mechanism of cell growth and proliferation disorders and diseases. Chinese medicine believes that the formation of tumors is the first loss righteousness, put together by the evil, caused by a series of diseases. Local recurrences and distant metastases develop in patients with early stage NSCLC ( Non-small Cell Lung Cancer) after surgery. Traditional Chinese Medicine believe that the human body is an organic whole. Internal organs and external body surface, limbs, facial features are the same overall. On the one hand to directly kill cancer cells, On the other hand to rebuild their anti-cancer immune system, control of recurrence and metastasis. Cancer Treatment and improve the bodys immune system is at the same time.

First, the use of Chinese medicine to control and conditioning during the tumor treatment. Killi tumor cells by take Chinese medicines and Western medicine to Control progression of the disease, to improve their physique for surgery.

Secondly, during the surgery and chemotherapy, Chinese medicine can increase the effects of cancer treatment. Reduce side effects to control the chance of tumor recurrence and metastasis.

Third, after surgery, After surgery and following 2 months of rehabilitation program. Chinese medicine can consolidate the curative effect, improve the treatment success rate. Recommendation: use of traditional Chinese medicine and Western medicine combined treatment under the guidance of doctors.

Western medicine also improved the immune system, But with drug metabolism, if not continuous medication, difficult to maintain immune function. After tumor surgery, Western medicine often use the chemotherapy, radiotherapy and other treatment methods, but with a lot of side effects, serious impact on the lives of patients. TCM with minimal side effects, Traditional Chinese Medicine (TCM) therapy is effective in treating malignant tumor.

Alexandria Alternative Medicine Practitioners

Posted on December 27, 2018 by admin

Traditional practitioners commonly treat pain and other ailments. However, Alexandria alternative medicine practitioners offer more choices for the individual who wishes to take a different path toward wellness. Among the alternatives offered for medical treatments are acupuncture, acupressure, massage, bodywork and therapeutic massage.

Acupuncture is a Chinese medicine practice used to relieve pain. It is alternately used for therapeutic purposes. The procedure consists of inserting thin, disposable, stainless steel needles into specific points of the body in a near-painless experience. The needles are then manipulated to control what is known as “qi” or blood flow. Traditional Chinese medicine is based on treating “patterns of disharmony” instead of biomedical treatments.

Acupressure, on the other hand, can be thought of as a mixture of acupuncture and pressure together. It is another alternative medical technique that is derived from acupuncture, only physical pressure is applied to the points in the body that would normally be treated with needles during acupuncture. In acupressure, these areas are called, “acupoints.”

The practice of acupressure is controversial, as are most alternative treatments. However, many people report to have benefited from the practice.

Massage or massage therapy is another alternative medicine treatment that is used to treat stress, headaches, muscle aches and other pains, as well as for total relaxation. It is also used to alleviate lower back pain, which helps improve range of motion. Pregnant women often use massage therapy to help them during labor to have easier experiences. It also serves the purpose of helping to ease the dependence on addictive medications. The motion of massage therapy is said to enhance immunity by positively affecting the lymph flow. It has also been used to help athletes recover from injuries.

Massage therapy has also been known to help people who suffer from depression and anxiety as well as migraine headaches.

Bodywork is a therapeutic treatment that focuses on manipulating the energy fields that are associated with the body. The therapys practitioners hold the view that a lot of health conditions result from issues with the physical aspects of ones body such as tight muscles, tension or a blockage of some times. Types of bodywork include Rolfing, lymph massage, Shiatsu, lomi-lomi and other deep tissue massage techniques. This method of treatment is being used more and more in mainstream sports medicine.

Therapeutic massage is used in the same way as bodywork, but does not always include deep tissue massage. It is used to treat tension, anxiety, stress and any number of other ailments. While used in some mainstream practices, therapeutic massage is ultimately considered an alternative medicine practice.

Medicine and Positive Thinking – Healing and Health with Positive Thinking

Posted on December 24, 2018 by admin

Positive thinking has, for the longest time, been relegated to the realm of new age, inspirational, and metaphysical healing rather than to the empirical fields of science and physiology. Medicine and positive thinking, therefore, were once thought to go together like brownies and onions. But recent findings have revealed that medicine and positive thinking may not be as incompatible after all. Indeed, they may actually be far more complementary than we could ever imagine.

Not only is positive thinking good for mental health, but it is now scientifically proven to be just as healthy for the body. Optimists generally have lower levels of stress hormones and are at lower risk for cardiovascular disease – telltale signs of a healthier immune system-compared to those of pessimists. Positive thinkers are also more likely to get well faster during treatment for a physical illness.

If negative factors like anxiety and stress can adversely affect a person’s physical well-being, then it should follow that positive thinking has a reverse effect. The only reason this hasn’t been readily accepted as truth before is because for years, we have tended to focus more on the negative, measuring and quantifying depression and such while the scales of happiness remained uncharted.

Research has repeatedly shown that chronic and psychological stress delays the healing process, reduces vaccine effectiveness, and diminishes the immune system’s health. Here, at least, we have known that there is, in fact, an obvious connection between what you know and feel in your head and how your body responds to it. Literally, you are what you think.

Medicine and positive thinking are hardly interchangeable, but they work wonders when taken hand in hand. So when you’re sick, expect positive results. Picture yourself in the prime of health; or if you want to be more realistic, visualize yourself recuperating from your sickness. Laugh your way to recovery. That is the best medicine, after all, according to the well-known proverb.

Positive expectations, like the placebo effect, can greatly reduce pain; thus, proving the innate power of an optimistic outlook in life. So do yourself a favor by thinking positive and helping yourself get better.

Medicine and positive thinking do work famously together. It is not believing in a false hope, but rather embracing the beauty of life despite its many setbacks. Positive thinking was never meant to be a miracle cure, but if you focus on living instead of drowning in anger, sorrow, and self-pity, you may just find yourself thinking your way to health and wellness.

Michael Lee is unbelievably giving away over $2355 worth of the best self-help ebooks FREE at http://www.20daypersuasion.com/goldaccess.htm so take advantage now before it’s too late!

Category: Medicine