Targeting Cancer Stem Cells Therapeutic Strategies, Drug Development Pipeline, Biomarkers And Diagn

Cancer Stem Cell (CSC) research has accelerated in the last two years and considerable efforts are now being made to identify drug molecules that selectively target and destroy them. Today, 50 developmental molecules are being evaluated in the hope of targeting this subset of cancer cells. More than 40 companies and commercial groups are progressing these activities and around 20 drug-targeting strategies are being evaluated. Efforts are being made to target CSCs using novel single agents as well as combinations, based on new and established classes. This 2010 report gives a comprehensive update on current therapeutic and diagnostic development in this field, on the drug development pipeline and the most promising research areas in CSC characterisation. New therapeutic and diagnostic opportunities in this field are also presented.

Background: Many cancers contain a subset of stem-like cells believed to play a critical role in the development and progression of the disease. These cells, named Cancer Stem Cells (CSCs), have been found in leukaemia, myeloma, breast, prostate, pancreatic, colon, brain, lung and other cancers. Findings suggest that CSCs are able to seed new tumour formation and drive metastasis. CSCs also show resistance to a number of chemotherapy drug classes and radiotherapy which may explain why it is difficult to completely eradicate cancer cells from the body, and why recurrence remains an ever-present threat. If these findings are confirmed in the clinic, the targeting of CSCs alongside the bulk of other cancer cells will offer a new paradigm in cancer therapeutics. Currently, there are more than 50 CSC R&D programmes in progress, around 50% of which are at Phases I-III. Patient data from the first clinical trials on CSC-targeting drugs are now being reported. More than two thirds of CSC R&D programmes are being taken forward by SME’s, and >90% of the patents in this field have been filed by Universities. Substantial opportunity for collaboration exists in this field, and this has lead to agreements between SMEs and number of international pharmaceutical companies.

Drug Pipeline: Approximately 20 different strategies, which are described in this report, are being pursued in the hope of discovering ways of selectively targeting CSCs. Recently for example, at the CTRC-AACR San Antonio Breast Cancer Symposium in December 2009, data were presented on the targeting of chemotherapy-resistant breast CSCs with the Merck compound MK-0752, a gamma-secretase inhibitor that targets the Notch pathway. In a study involving 35 women with advanced breast cancer, biopsies revealed reduced numbers of breast CSCs. In this particular case, it was suggested that combination therapies involving agents that also target the Notch pathway (believed to be important in CSC renewal) may offer more powerful strategies for killing resistant CSC populations.

Cancer Diagnostics: CSCs are believed to be causally linked to the development and metastatic spread of cancer. If this is confirmed in the clinic, this will place CSCs at the heart of cancer diagnostics and biomarkers. Scientists have identified a number of surface proteins, such as CD44, CD133 and many others, that may have important utility in both of these areas. A number of intracellular markers found in CSCs may also have diagnostic utility. These developments are described in this report. For example, CD133 mRNA levels in peripheral blood, measured using RT-PCR, have been found to predict colon cancer recurrence. There is a need for new methodologies that isolate and characterise circulating tumour cells (CTCs) in the blood, and can be applied to CSCs. CTC technologies using the EpCam marker to isolate these cells are able to predict breast and colon cancer recurrence. The adaption of these techniques, based on specific CSC phenotypes, may provide sensitive new methods for identifying CSCs in the body. If this is achieved, it will have important implications in therapeutic decision-making and monitoring.

This 2010 report gives a comprehensive and up-to-date review of global R&D on CSCs, and strategies to target them. This includes around 40 companies or commercially based research organisations (including 27 SMEs and 8 international pharmaceutical companies) that are progressing drug discovery activities, including drug pipeline (pre-clinical to Phase III), discovery strategy, candidate molecules, drug targets, clinical trials and related areas.

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Severe Breast Cancer Symptoms

Breast cancer is the most common form of cancer in women, and one of the most common types of cancer in general. It is estimated that one in seven women that live to age 90 will develop breast cancer. It is especially prevalent in some families, making the statistics a bit skewed. If you have a family history of breast cancer, your chances of developing the disease are much greater. Its therefore a good idea to stay especially vigilant for breast cancer symptoms. Breast cancer symptoms dont often manifest themselves until the cancer is already in its later stages of growth, and may have already metastasized to other more vital areas of the body. That is why it is so important for women to regularly get checked. Mammograms may be unpleasant, but late stage breast cancer symptoms are worse.

The most clear and common breast cancer symptom is of course a lump in your breast. It is important to keep in mind that not all lumps are cancerous. Most women will develop numerous lumps in their breasts throughout their lives; they are especially common during periods of rapid hormonal changes such as puberty, and menstruation. Some women will have more lumps than others.

A more severe breast cancer symptom will be pain in your breasts. A cancer that has grown large enough to impinge on nerves will be a noticeable lump in a self check or mammogram, so hopefully youll catch anything before it gets to the point of causing pain. If one or both of your breasts are in pain, again its important to keep in mind that you dont necessarily have breast cancer. During puberty and periods of hormone fluxes, tenderness of the breasts is common. Also pregnancy, and some medications can cause pain or tenderness in your breasts.

Even though most cases of breast cancer are diagnosed in women over 40, women in their teens and twenties are occasionally diagnosed as well. Most people dont know that about one percent of the cases are in men. Starting from puberty, it is a good idea to start checking yourself for lumps. Remember, during this period youre likely to find a lot of lumps that are harmless. With some experience and some consultation with your doctor, youll soon get an idea of the kinds of lumps that are normal, and the kinds of lumps that may be breast cancer symptoms.

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Lung Disease, Asthma, Emphysema, Bronchitis And Lung Cancer Common Causes And What You Can Do

Asthma is the most commonly known lung disease, and is increasing in number. Other disorders include chronic bronchitis, emphysema and lung cancer. There have been many theories offered as to their origin, including genetic, allergic and neurologic. My experience leads me to believe that all of these disorders have a common cause – hyperexcitability of the cell membrane.

The cell membrane surrounding the cell has many functions, including control of acid, water and salt balance; transport of nutrients into the cell; excretion of toxins and waste products out of the cells; and intercommunication with other cells. These activities of the cell membrane generate an electrical charge and this excitability enables the cells to respond to external factors. When the cell is under stress from chemicals, infections, toxins, low energy states and emotional stress, there is an increase in the excitability or electrical activity of the cell membrane. Cell membrane hyperexcitability is a common factor in many diseases because it results in various cell changes, including decrease of energy, muscle contraction or spasm, inflammation, decreased immune function, fibrosis (scarring) and degenerative disease. If continued long enough, it can lead to cancerous changes.

So, rather than a multitude of potential causes of lung disease, I believe that there is a primary one – cell membrane hyper-excitability. And rather than there being many discrete diseases of the lung, there is actually a spectrum of diseases that have a common pathophysiology (the mechanism of disease production).

As we stated in our published article “BRONCHIAL EPILEPSY OR BRONCHO-PULMONARY HYPEREXCITABILITY AS A MODEL OF ASTHMA PATHOGENESIS” (published in Medical Hypotheses 2006, 67, 1042-1051), each of these pulmonary diseases (asthma, COPD/emphysema and lung cancer) may be a single entity in a spectrum of diseases caused by the same underlying mechanism: excitatory dysfunction.

Research has also shown that those patients with chronic asthma, bronchitis and emphysema are more likely to have lung cancer in later life.

What can you do about it?

If there is indeed one pathway to lung disease, there must also be a similar but opposite pathway to lung health.

Benefits of Healthy Diet & Hydration

How do we reverse cell membrane hyperactivity? A healthy diet is the first step. It is the source of life and energy for your cells. Without this invaluable energy, cells must adapt to living with low energy by increasing electrical activity. The worst dietary offenders for cell health are sugar, salt and excess iron (as in red meat).

Some of the simplest nutrients that support lung health are magnesium and omega-3-oil (fish oil), both of which are cell membrane calming agents. I saw a seven-year-asthmatic boy last year whose mother was enthusiastic about getting him off asthma medicines. I suggested that he add fish oil and magnesium to his diet for two or three months. Amazingly, he has been off medications ever since.

Hydration is a very important factor to combat asthma, as dehydration (such as with exercise) causes a release of histamine (excitatory neurotransmitter) which can aggravate bronchospasm. Any supplement that relaxes hyperexcitability is helpful for asthma, including glycine, GABA products, and herbs with these same membrane-calming properties.

Excitement, Anxiety are Triggers

Excitement and anxiety are known to be common triggers for asthma. In my practice, fear, anxiety and especially grieving tend to be common in patients with long-term lung health issues.

I treated a young lady several years ago with an intractable fungal infection of her lungs. Nothing seemed to improve her. After over a year of various treatments, she realized that her grieving over a lost boyfriend had preceded her lung disease. After becoming aware of this, she slowly started to improve. (Coincidentally, my last three female patients who had lung cancer all reported a feeling of grief over lost ones or lost relationships.)

One of the most interesting aspects of this hyperexcitability theory is that there are neurotransmitter sites on the cell membrane that affect electrical activity. Acetylcholine, histamine and glutamate are examples of stimulatory neurotransmitters that heighten cell excitability, whereas relaxing neurotransmitters like GABA and glycine have the opposite effect.

Neurotransmitters are the vehicles of our emotions. Simply put, anxiety-producing neurotransmitters stimulate the hyperexcitability of the membrane, whereas relaxing emotions have beneficial effects on the cells’ excitability.

Five Tips for Healthy Lungs

Making healthy lifestyle choices, including a healthy diet, moderate exercise and stress reduction, is a good starting point. (Amazing how these three habits seems to promote almost all organ health.) My recommendations for everyone concerned with lung health are:

1. A healthy diet free of excess sugar, sodium salt, iron, MSG (a glutamate derivative) and nicotine (a cell membrane excitatory chemical).
2. Relaxation. Some of the common methods of relaxation include breathing exercises, meditation and exercise.
3. Hydration. Remember to keep hydrated, especially if you exercise.
4. Several specific membrane-calming agents that have helpful affects on lung health are magnesium, omega-3-oil (fish oil), GABA, glycine, vitamin D, and herbs like sophora.
5. An herbal combination that can be used to promote overall lung health is found in Get Well Natural’s Breathe Well formula containing sophora, morinda, atractylodes, schizandra, cudrania, and poria. It’s a supportive formula for healthy lung, immune, and cellular function.

Dangers Of Lung Cancer

The cause of lung cancer has been seen to be the abnormalities in cells. The body of human beings automatically regulates the production and growth of cells when the body needs them. If there is uncontrolled growth of cell in the tissues of the lungs, then final results may be developing of lung cancer.

Symptoms of lung cancer vary depending on the location and the spreading effect of the tumor but one cannot easily identify early warnings of lung cancer. The best thing one can do is consult a doctor in cases of a new persistent cough or the worsening of an existing chronic cough, if there is blood in his sputum, chest pains and difficulties in breathing and unexplained weight loss

Cancer of the lungs can be categorized into primary lung cancer and Mesothelioma. The primary lung cancer is cancer that starts in the lungs while the Mesothelioma or also referred to as secondary lung cancer normally results when the origin of the cancer was from another part of the body spreading to the lungs. The causes of lung cancer can be through smoking, radon gas, asbestos or viruses not forgetting the genetic risk.

Smoking: Smoking of cigarettes is the leading cause of lung cancer. In the developed world, cigarette smoking accounts for more than 80% of lung cancer related deaths. People who start smoking at a tender age are at a higher risk of developing lung cancer earlier in life due to the high exposure period. Non-smokers can also develop this type of cancer when they inhale smoke released by smokers found in their midst. All these modes are equally dangerous that is, the active pipe or cigar smoker and the passive smoker.

Radon Gas: This gas is natural in occurrence and is known to pass from the soil to building foundations. Exposure to these gases will very much vary as per the locality and the underlying soil and rocks in that area.

Asbestos: Individuals who have had prolonged contact with asbestos stand a higher chance of developing lung cancer especially in the event they do smoke for the combination of asbestos and tobacco will tend to act as one thus increasing the risks. Heavy exposure to asbestos may result to far greater risks of developing lung cancer.

Viruses: In early times, viruses where thought to only cause lung cancer in animal. However, recent studies show that they can cause cancer I humans too. These viruses include JC virus, simian, papillomavirus and others.

To prevent lung cancer, people should stop smoking.

Got Cancer Why You Should Drink Pau D’arco Tea!

Information and first hand knowledge.

I was diagnosed with stage 4 stomach cancer which had metastasized to my liver and given an average of 6 months to live…that was almost 7 years ago.
I firmly believe I am alive today as a result of drinking pau d’arco tea. This is a brief outline of the properties and benefits of pau d’arco tea in laymans terms and why in my opinion anyone diagnosed with Cancer (or many other serious disease’s) should drink the tea.

Pau d’arco bark contains many germ-killing substances. The incredible healing effects that pau d’arco tea has become known for are the result of the complex interactions of the inner barks many properties. That is why it is important to take the time to make and drink the tea in its complete and natural form. Many times the so called “active” substance is isolated and stripped away from a plant or herb and manipulated into something completely different from its natural form….losing all the synergistic activity that good old Mother Nature intended.

The healing substances found within pau d’arco are very significant when taken by Cancer victims. They can inhibit tumor growth, kill cancer cells and prevent metastases. Bernhard Kreher a Munich researcher wrote his doctoral work on the immuno stimulating effects of Pau d’arco and found that the body’s defense system activity increased by more than 48% when Pau d’arco was regularly consumed.

Pau d’arco contains a large amount of iron and calcium which help oxygenate and strengthen the bodies tissue and immune system. It also contains selenium a powerful anti-oxidant that removes free radicals which can damage cells and trigger disease – including Cancer.

Pau d’arco tea has a holistic effect on the body, meaning the whole body is detoxified. Harmful toxic substances, including heavy metals, pesticides, preservatives and even the residue from chemotherapy are more thoroughly eliminated. Blood vessels, the lymph system, cells, tissue and organs are all cleaned and detoxified allowing the bodies systems to function properly and efficiently.

Despite careful research there are no reports of any negative interactions of Pau d’arco with medications…Pau d’arco instead has demonstrated that it can combine with and enhance many other herbal applications…that is why many herbal blends contain pau d’arco among their ingredients.
One of the great benefits I found was that you feel and see the tea working so fast, my first scan was about 6 weeks after starting to drink the pau d’arco tea and it already showed significant tumor shrinkage….it is also very easy to prepare…

Brewing Instructions…In a stainless steel or glass pot add 3 tablespoons of Pau d’arco to 1 quart/liter of water (I always brew a gallon at a time), bring the liquid to a full boil with the lid on…then keeping the lid on reduce the heat so the tea is at a gentle boil for 25 minutes…let it cool and pour through a funnel and tea strainer into sterilized bottles, you can sterilize any bottle by heating it in the oven at 225 degrees for 10 minutes, I found a great source for bottles in washed out liquor bottles . Refrigeration is optional as the strong anti bacterial properties in the tea prevent any spoiling…I just sit mine on the counter because I think it tastes better at room temperature.

It is recommended that if you are drinking the tea for cancer reasons then a minimum of four, eight ounce cups per day should be drank, I consumed six or seven cups on average per day until the tumors were no longer visible on the scans, then fell back to my present dose of 2-3 cups per day…

Incidently I also can’t remember the last time I caught a cold even though many around me have been hacking and sneezing…another great benefit of the strong anti-bacteria and virus killing properties found in the tea.
The most important thing is to buy quality pau d’arco…you want the correct species Tabebuia Avellanedae 100% inner bark in a fine grind…I searched for and tried many pau d’arco sources, some offer it for as little as $5 per pound but believe me you get what you pay for…the less expensive tea tasted very weak and came as shavings or lumps of bark …not at all like the proper fine grind. I know of only two sources in North America that directly import from Brazil the correct species of fine grind inner bark…
Herb-Care and Prince.

Of course there are no 100% guarantees of a cure but many people have beaten the odds using this tea ….and happily I can say I am one of them!

[This article was dictated to the Author and is free to copy in its entirety provided all links and text are intact and unaltered.]

Bladder Cancer – Global Drug Forecasts And Treatment Analysis To 2020 – Volume 1 2011

GlobalData analysis finds that the global bladder cancer therapeutics market is moderately attractive and is primarily driven by growth in the patient volume and growth in the cost of therapy. The patient volume was driven by growth in treatment usage pattern measurements such as diseased population, treatment seeking population, Diagnosed Population and prescription population.

In 2010, the bladder cancer therapeutics markets key markets (the US, UK, Germany, France, Italy, Spain, Japan, Brazil, Russia, India and China) were collectively worth $610m. The markets size is driven by two key parameters, namely the patient volume and the annual cost of therapy per patient. Between 2001 and 2010, the global bladder cancer therapeutics market grew at a CAGR of 8.0%.

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The bladder cancer therapeutics market is completely dominated by generic drugs such as methotrexate, cisplatin, vinblastin and doxorubicin. BCG (Bacillus Calmette-Gurin) therapy and mitomycin C are the other drugs that are used for the treatment of bladder cancer.

Gemcitabine was the top-selling drug in the bladder cancer therapeutics market in 2010. The other leading drugs in the market in 2001 were BCG therapy and methotrexate which registered sales of $55m and $57m. In 2010, gemcitabine was the leading drug in the bladder cancer therapeutics market, with sales of $170m. Methotrexate and BCG therapy were the other leading therapies with sales of $145m and $131m. Between 2010 and 2020, three promising therapies, Javlor (vinflunine), Urocidin (intravesical formulation of Mycobacterial cell wall-DNA complex (MCC)) and EOquin (apaziquone), are expected to hit the market. Between 2010 and 2020, the market is expected to be led by Urocidin, with forecast sales of $386m.

GlobalData, the industry analysis specialist, has released its new report, Bladder Cancer – Global Drug Forecasts and Treatment Analysis to 2020 Volume 1 2011. The report is an essential source of information and analysis on the global bladder cancer therapeutics market. The report provides comprehensive information on bladder cancer, highlighting the treatment guidelines. It identifies and analyses the key trends shaping and driving the global bladder cancer therapeutics market. It analyses the treatment usage patterns in the global bladder cancer therapeutics market. The report also provides insights into the competitive landscape and the emerging players expected to significantly alter the positions of the existing market leaders. The report provides valuable insights into the pipeline products within the global bladder cancer sector. It quantifies the unmet need in the global bladder cancer therapeutics market as well as in the individual markets such as the US and the top five countries in Europe, highlighting the opportunity for future players.

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Cancer, Drysol, And Your Armpits

You’re out shopping and see Drysol on the shelves. You consider buying the product because your friend has told you so much about it. You haven’t. Take a close look at the product – do you know for a fact that it’s risk-free to use?

Dismiss the question all you want, but that does not change the fact that there are those who worry about it. In fact, there is a raging debate over the likelihood that Drysol may cause cancer. Studies have shown that Drysol and other perspirants like it contain chemicals that affect hormones, which then stimulates malignant cells. In particular, a number of studies indicate that breast cancer may be tied to the usage of underarm deodorants.

These days, you can find large amounts of information on the connection between cancer and genetic predispositions. While there may not be gene tests available yet, you should be very careful about using Drysol, especially if a family member has had breast cancer. Why? It’s simple really – cancer tends to appear in families. I don’t mean to scare you, but family history is always a good gauge of whether you will develop cancer or not later in life.

Without a question, manufacturers of certain chemicals have been fighting to prove that their products pose no danger to consumers. Companies that produce aluminum chloride are one of them. But you cannot hide as major an issue as toxicity from consumers. What this tells you is that you should never rely on what marketing pitches tell you about Drysol.

Sometimes, it seems like every product under the sun can cause cancer However, do not dismiss the connection out of hand because it may very well be true. As may be expected, manufacturers of Drysol and other potentially harmful products would prefer you think that all these warnings are just media sensation. But would you really put yourself at risk, testing the product on yourself? By that time, you may not even remember that you used Drysol at some time in the past, let alone have the mental wherewithal to seek damages for your condition.

Cancer is a terrible thing to deal with; but as early as now, you can take steps to avoid it. A great way to do this is by avoiding anything thay can harm your DNA and your cell makeup. Avoid using Drysol as much as possible. It’s not far off that one of these days, newer research just may single out deodorants like Drysol as cancer-causing so be very wary, be very careful, and be very watchful for natural alternatives you can try, instead of Drysol.

Cancer Disease The Most Common Killer In The World

What is it?

Cancer (medical term: malignant neoplasm)is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood).[1] Cancer affects people at all ages with the risk for most types increasing with age.[2] Cancer caused about 13% of all human deaths in 2007[3] (7.6 million).

These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, and do not invade or metastasize. Most cancers form a tumor but some, like leukemia, do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is oncology. [1]

Cancers are caused by abnormalities in the genetic material of the transformed cells.[4] These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may randomly occur through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers is usually affected by complex interactions between carcinogens and the host’s genome.

Classification

Cancers are classified by the type of cell that resembles the tumor and, therefore, the tissue presumed to be the origin of the tumor. It describes a large amount of human diseases with very diverse qualities. Examples of general categories include of Carcinoma, Sarcoma, Lymphoma and Leukemia, Germ cell tumor and Blastic tumor. Malignant tumors (cancers) are usually named using -carcinoma, -sarcoma or blastoma. For instance, the most common type of breast cancer is called ductal carcinoma of the breast or mammary ductal carcinoma. [1]

How was human get the disease?

In most individual cases of cancer, the exact cause of cancer is unknown. The causes may include increased genetic susceptibility; environmental insults, such as chemical exposure or smoking cigarettes; lifestyle factors, including diet; damage caused by infectious disease; and many more.

Anything which replicates (living cells) will probabilistically suffer from errors (mutations). Unless error correction and prevention is properly carried out, the errors will survive, and might be passed along to daughter cells. Normally, the body safeguards against cancer via numerous methods, such as: apoptosis, helper molecules (some DNA polymerases), possibly senescence, etc. However these error-correction methods often fail in small ways, especially in environments that make errors more likely to arise and propagate.
Researches about cancer reveal that this type of disease can be cause by these following categories:
Agents (e.g. viruses) and events (e.g. mutations) which cause or facilitate genetic changes in cells destined to become cancer.
The precise nature of the genetic damage, and the genes which are affected by it.
The consequences of those genetic changes on the biology of the cell, both in generating the defining properties of a cancer cell, and in facilitating additional genetic events which lead to further progression of the cancer.

Preventions

Cancer prevention is defined as active measures to decrease the incidence of cancer. More than 30 percent is prevent by avoiding risk factors including tobacco, overweight, or obesity, low fruit and vegetable intake, physical inactivity, alcohol , sexually transmitted infection and air pollution. [5] This can be accomplished by avoiding carcinogens or altering their metabolism, pursuing a lifestyle or diet that modifies cancer-causing factors and/or medical intervention (chemoprevention, treatment of pre-malignant lesions).

Cancer Treatments

There are four standard methods of treatment for cancer: surgery, chemotherapy, radiation therapy, immunotherapy and biologic therapy. Clinical trials may be an option for some as cancer treatment who meet certain study criteria. Others may choose alternative cancer treatments. Some of the alternative treatment include of strengthening the immune system by taking Vitamin C intravenously each day
When initially diagnosed with cancer, a cancer specialist, an oncologist, will provide you with the cancer treatment options. He or she will recommend the best treatment plan based on your type of cancer, how far it has spread, and other important factors like your age and general health.

Cancer Screening

According to the American College of Obstetricians and Gynecologists, cervical cancer rates have fallen more than 50% in the past 30 years due to the widespread use of the Pap test. The life-saving benefits of mammograms are less clear. A 2003 study gave the following figures: two out of 1,000 women in their 40’s, four out of 1,000 in their 50’s, and six out of 1,000 in their 60’s are saved. [5]

The American Cancer Society recommends that even people with no symptoms go see a physician for cancer screening. Early detection is one of the best weapons we have against cancer. Usually when a patient already has symptoms, the cancer has spread (metastasized). This makes curing it more difficult with the treatments offered today.

Radiation Therapy

The discoveries of x-rays and radiation by scientists Becquerel and Rontgen in the late 1800s got the ball rolling in radiation application. Marie Curie’s Nobel Prize winning work with radioactive elements also helped set the stage at the turn of the century.

Scientists and doctors, out of happenstance, discovered that radiation regressed or slowed some tumors according to some studies on record. They were ignorant of the specific reasons why, but the first radiation oncologists cured, from historical record, the first cancer case in 1898.

They were mostly cures of superficial cancers and the reoccurrence of tumors in treated patients were high due to the unrefined nature of the radiation application methods and the massive doses or radiation given.

Alternative Cancer Diet That Cures Cancer

On day 1 the patient has no nourishment, except 250 ml of flaxseed oil with some freshly squeezed fruit juices with no sugar and honey. If the patient is extremely ill then fruit juice may be replaced with champagne. Besides, all these this must be avoid, it is include of animals fats, all meats(hormones and chemicals), all salad oils, margarine, butter, and preserved meats.

Vegetable juices that are freshly squeezed are fine – apple, carrot, red beet, celery. Warm tea is also very important; it should be consumed three times a day – grape tea, rose hips, and peppermint – sweetened with honey.

Here is Dr. Budwig daily plan [6]:
A glass of Sauerkraut juice or Acidophilus milk is taken before breakfast.
Breakfast consists of Muesli with with two tablespoons of flaxedd oil, fresh fruits and honey. You can vary the fruits from day to day if you want. Nuts are good except peanuts. Black tea or herbal tea. A 120 g serving of the The spread
Morning tea at 10 am for example or/and a glass of fresh juice. (apple juice, carrot juice, celery, beet-apple juice.) Raw salad with yoghurt-Flaxseed Oil MayonnaiseGrated turnips, carrots, cauliflower, radishes, sauerkraut, or kohlrabi in addition to greens salads. Parsley, horseradish and chives may be added for flavour.
Cooked meal – Steamed potatoes, vegetables or grains like rice, millet or buckwheat may also be served. Then add The Spread and The Mayo to these for flavour.
Dessert – Fresh fruits mixed with The Spread and flavored using cream of lemon, vanilla, or berries instead of honey.
Afternoon tea – A small glass of chamapaigne or natural wine with no preservatives or fresh fruit juice with 1-2 tablespoons of Flaxseeds covered with honey.
Supper – Use oat, buckwheat or soy cakes to make a hot meal. Grits from buckwheat are perfect and can be added in a vegetable soup or in a more solid form of cakes with some herbal sauce. Only honey orgrape juice can be used for sweeteners.

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Article Resources:
1.http://en.wikipedia.org/wiki/Cancer
2.Cancer Research UK (January 2007). “UK cancer incidence statistics by age”. http://info.cancerresearchuk.org/cancerstats/incidence/age/. Retrieved 2007-06-25.
3.WHO (February 2006). “Cancer”. World Health Organization. http://www.who.int/mediacentre/factsheets/fs297/en/. Retrieved 2007-06-25
4.Kinzler, Kenneth W.; Vogelstein, Bert (2002). “Introduction”. The genetic basis of human cancer (2nd, illustrated, revised ed.). New York: McGraw-Hill, Medical Pub. Division. p. 5
5.http://www.emedicinehealth.com
6.http://naturalcancertreatmentsthatwork.blogspot.com/

Colon Cancer Signs Are All The More Deadly For Being Subtle

Colon cancer warning signs should not be taken lightly. As we get older, it is important to know about and be able to recognise colon cancer warning signs. Many colon cancer warning signs are not apparent in the early stages and being aware of the problems could prove vital to a better prognosis.

Cancers of the colon and rectum are usually discussed together under the name colorectal cancer, but its common name is colon cancer. Cancer occurs when abnormal cells grow out of control on the wall of the colon. In some instances, symptoms may be from a condition other than cancer, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and sometimes diverticulosis.

In the colon andrectum, this exaggerated growth may cause precancerous polyps(adenomas, or adenomatous polyps) to form in the lining of yourintestine. Over a long period of time (spanning up to several years) some of these polyps may become cancerous. In later stages of the disease, cancerous polyps may penetrate the colon walls and spread to lymph nodes and other organs.

Once you have warning signs of any illness you should visit your doctor for diagnosis. Some very early colon cancer warning signs are:

* Blood in your stool or darkened stools
* Change in bowel habits, either loose stools or constipation
* Pain in your abdomen or pain during bowel movements
* Feeling tired when you have had enough rest

Colon cancer symptoms later on are:

* Pain in the lower abdomen area
* Feeling very tired
* Infrequent cramps along with difficult bowel movements
* Nausea if you are taking certain drugs or receiving radiation treatments

Just so you know colon cancer warning signs are normally not visible to the naked eye, but if you are aware of your health conditions, you could use colon cancer warning signs to your advantage. One of the early warning signs of colon cancer is problem in passing stools. Known as constipation, it is considered to be a very easy early warning signs of colon cancer in your body.

Abdominal cramps and bloody stools in some cases are among other things known as classic warning signs of colon cancer or early warning signs of colon cancer. Again, pain in the colon could be attributed to a lot of other body disorders, but you can definitely consider it as colon cancer warning sign.

It is only in the later stages of the diseases that the patient starts developing colon cancer warning signs in any or all of these symptoms. Many cases of colon or colorectal cancer have no symptoms or warning signs until the cancer has advanced. If you experience any of these warning signs, you should see your doctor right away.

It is vital that you seek medical attention as soon as you suspect any problems. An early diagnosis could save your life as it has usually reached an untreatable stage by the time you experience any colon cancer warning signs.

Aquarius And Cancer Love Match And Astrology Relationships – Relationship Or Fling

Cancer’s warm, responsive character is chilled by Aquarius’s excellent self-possession. In change, Cancer’s clinging, cloying demonstrativeness makes Aquarius feel hemmed in. Aquarius is quickminded, unpredictable, apt to be impatient with cautious, hesitant Cancer. And thin-skinned Cancer is quickly damage by Aquarius’s caustic humor. Cancer doesn’t recognize Aquarius’s necessary detachment. Most cancers needs to feel close and secure; Aquarius is a lone wolf. Sex may be all right, but there’s puny different heading for them.

Aquarius bristles at Cancer’s possessiveness and can’t understand why Cancer won’t cling loose. Aquarius is careless and free with affection, creating sensitive Cancer feel neglected and rejected. Aquarius dislikes Most cancers’s clinging restrictiveness and complaining, which stem from Most cancers’s frequent need for proofs of love. Most cancers desires a safe, safe home, but Aquarius should a very flexible living arrangement. Most cancers desires Aquarius to stay, but quickly Aquarius is inclined to wander away.

Please notice which sun signal compatibility is generalized. There are 11 various planets and 12 houses in the delivery graph that influence the general personality of an individual.

Don’t choose the partnership only from the sun sign. Other planets in your beginning chart possess various effects on various component of your romantic relationship and compatibility. To understand the roots of any relationship problem, to forecast your romantic relationship and to improve you comprehend your partner better, get the astrology compatibility evaluation now!