Fight Breast Cancer With Calcium D-glucarate And Other Nutritional Supplements

Most likely, there is nothing more frightening for a woman than the discovery of a lump in her breast. Her mind is quickly flooded with cancer and all of its consequences. Most women have a friend, a sister, or a coworker who has been diagnosed with the disease and know how difficult dealing with it can be. Fortunately, 80% of all breast lumps are not cancer, as most are cysts or a benign clump of tissue. From puberty on, a womans breasts undergo many changes. Because of these continual changes, breast tissue requires adequate nutrition. Although everyone benefits from a healthy diet, there are additional nutrients which can specifically benefit women including B vitamins, calcium D-glucarate, broccoli extract, green tea, maitake mushrooms, and iodine.

Because scientists can learn a lot about diseases from simply observing it, they have learned that certain cultures have a very low incidence of breast cancer, among these being China and Japan. As compared to women in America, Canada, and parts of Europe, the Asian cultures have a much lower breast cancer rate and it seems likely that something in their diet could be protecting these women from the disease. As Asian women adopt a western diet their breast cancer rates climb. It has also been recognized that certain types of vegetables play a large role in the prevention of all types of disease, including cancer. Based on this, scientists have carried out many studies to determine what it is about these nutrients that can prevent breast cancer.

Deficiencies in vitamin B12 can result in a serious type of anemia, as well as nerve damage, and is now being researched to see if these deficiencies can also, in part, cause breast cancer. A scientific study proved that women who had the lowest levels of B12 in their blood had the highest rates of breast cancer. Another study discovered that when B12 was applied directly to cancer cells, it actually stopped cancer cells from growing. The researchers conducting this experiment believe that giving B12 to women with breast cancer as a part of a chemotherapy regime might help to keep cancer in check.

Similarly, low folic acid intake is linked to the development of all cancers because folic acid is crucial to the making and continual repair of DNA. A recent study discovered that high intakes of folic cancer may actually reduce the risk of breast cancer, as women who eat lots of foods that contain folic acid have much lower rates of breast cancer. Although there is no clear-cut, single cause of breast cancer, many factors are required for the disease to appear, including estrogen. Studies have shown that women who have higher levels of estrogen tend to develop breast cancer more often. This means that women who got the periods before age eleven or entered menopause after the age of fifty-five have a higher risk of breast cancer. Another factor affecting breast cancer is the consumption of alcohol. Since alcohol raises estrogen levels, a woman who consumes even moderate amounts of alcohol increases her risk of breast cancer. However a recent study has shown that folic acid can overtake this link between alcohol consumption and breast cancer as those women who drink one alcoholic drink a day and have high levels of folic acid have the same rate of breast cancer as those women with high folic acid intakes who did not drink.

While women need estrogen to soften skin, thicken hair, and fill out hips and breasts, estrogen can also nourish breast tumors and help them to grow bigger, stronger, and more deadly. Thanks to good nutrition, American women get their periods early and go through menopause later in life. Today, women also have fewer pregnancies, with the average number of children being one or two. Each of these factors increases the time in which womens bodies are exposed to estrogen, meaning increased opportunities for estrogen to cause trouble. We are also continuously exposed to cancer-causing chemicals and toxins, coming from contaminants in the food we eat and pollutants in the air we breathe. Although the body does have a system that eliminates some of the excess estrogen and toxic chemicals before they cause harm, an enzyme called beta-glucuronidase can interrupt the excretion process, allowing the hormone or toxin to continue to cause harm. Fortunately, scientists have discovered a natural substance found in foods, calcium d-glucarate (CDG), which can stop the activity of beta-glucuronidase. CDG, which is found in fruits and vegetables, has been shown in experimental studies to significantly slow breast cancer growth. There are also many other trials currently underway studying its ability to decrease the breast cancer risk in women at high risk for the disease.

Iodine, which is the trace element in a hormone found in the thyroid gland and is involved in several metabolic functions, functions as a protection of breast tissue from cancerous cells. A study exposing breast cancer cells and breast tissue without any cancer to a type of seaweed containing high amounts of iodine concluded that the seaweed killed all of the cancerous cells and did not harm the normal breast cells. Researchers believe that it is because many Japanese women eat this kind of seaweed, containing great amounts of iodine, that they have very low rates of breast cancer.

For a great deal of time, cruciferous vegetables including broccoli, cabbage, and cauliflower, have been observed by scientists for their ability to reduce the risk of diseases including cancer. It appears that the phytochemical sulforaphane, found in broccoli, is one of the chemicals responsible for this beneficial ability. Sulforaphane increases certain enzymes in the body called phase 2 enzymes, which deactivate cancer-causing chemicals. When breast cancer cells were exposed to sulforaphane in a lab experiment, the compound inhibited the growth of the cancer cells up to eighty percent.

There is a good amount of research that has concluded that green tea beverage consumption is associated with a lower incidence of breast cancer. Researchers have long noted the low rates of breast cancer in Japan, where green tea is consumed at great amounts. The active compound found in green tea that is responsible for breast cancer inhibition is EGCG, which stops the cells from growing, causes them to lose their ability to replicate, and die.

For many years, maitake mushrooms have been linked to good health in all that eat them, partly because they contain an important compound called D-fraction. D-fraction not only stops the growth of cancerous tumors, but it also alerts and stimulates immune cells to fight the disease. Due to its success, maitake is now being used in clinical trials of women with breast cancer, improving many symptoms including reduction of the tumor.

These nutrients should not be used in place of traditional treatment for breast cancer, as none of these nutrients can cure breast cancer. However, they can be a part of plan of treatment. If you have breast cancer, talk to your healthcare practitioner about these nutrients and remember that nutritional supplements are supplements to your food, medication, and treatment, to enhance and prevent, not a replacement. Supplements like B vitamins, calcium D-glucarate, broccoli extract, green tea, maitake mushrooms, and iodine can be found at your local or internet health food store.

Can Cancer Be Viewed As An Opportunity For Change And Ultimately Transformation

The circumstances surrounding cancer doesn’t have to be all negative. Cancer is the body’s way of saying: ‘You cannot go on like this forever…’ It has also been said that it is the body’s attempt to heal…so, can cancer be viewed as an opportunity for change and ultimately transformation?

Bearing this in mind the cancer sufferer would do well to ask: “Just how great are my intentions in producing the necessary changes for ending this disease and leading myself to a healthy transformation?” This is a very important question since some folks prefer death over making those vital necessary habitual lifestyle changes… .

Many people find it difficult to make those vital necessary changes, especially the ones that go against lifetime habits that have brought on the cancer. However, I can strongly recommend a very simple but effective methodology.

The method involves making simple steady changes, one at a time, on a gradient. For example, when going from unhealthy to healthy choices in nutrition, this means starting with making one small change, let’s say, in a dietary habit. Then, if comfortable with this small change in dietary habit over time, and not going back into the old, move on and make another one. Then, in the same way, if comfortable with this and not going back into the old habit move on to the next and so on… until, overall, those unhealthy nutrition habits no longer exist…

While the above goes on, other changes can be made such as those related to handling stress, avoiding environmental, chemical and electromagnetic toxins and I would greatly encourage other lifestyle changes such as getting into a daily exercise routine.

However, it must be emphasised that there must be no going back into old habits after each change… or otherwise the whole thing will come tumbling’ down. What about the timeline? Although the clock is ticking to make those vital necessary changes this is up to the cancer sufferer: Whatever is comfortable.

A very useful thing to do during this is to tell someone, a close friend or relative your intentions so that you can use them to hold yourself accountable to and they can indeed keep a watchful eye on you, to see that you’re adhering to those effective changes…

Remember your health is ultimately in your hands. Don’t be coaxed or cajoled or even bullied into doing something you feel is not right for you: I strongly hold the view that getting back on the highway to health means building a healthy immune system, which is what the above recommended changes are all about.

If you liked reading this article then go to www.NewParadigm.ws for more related articles including a free download PDF. NewParadigm is a portal to transformation, consciousness, spirituality, mind, body, health, alternative media and much more… Hosted by Paul A Philips. Once again the link is: http://www.newparadigm.ws/

How to Find the Best Cancer Center for Your Needs

Fighting cancer is an overwhelming experience that requires the support and love of your friends and family. You also deserve access to a quality cancer center that uses the latest methods and techniques to work on getting you well again. There are a variety of centers out there, so you’ll want to spend a little time researching them before you decide which one you think can help the most. Here are some tips and tricks you can use to find a high quality cancer center to work with:

Always Schedule a Consultation

It’s important to schedule a consultation appointment with any potential cancer center that you consider working with. This will give you an opportunity to tour the facilities and meet with doctors. Plan to spend a couple of hours at your consultation appointment.

Make a List of the Important Stuff

All of your questions and concerns should be written down so they aren’t overlooked when you meet with your new doctors. No question is too small to address, so don’t be afraid to fill the page. The more you know upfront, the less confusion or frustration you’ll have to deal with throughout your treatment.

Make Sure the Facility is Backed By Science

The center you are treated by should use techniques that are backed by solid evidence pointing to their effectiveness in fighting cancer. The last thing you need is to become a guinea pig for experimental treatments. Any reputable cancer center will be happy to discuss their treatment options and why they’re used with you upon request.

Talk to Other Patients

A great way to learn more about a cancer center is to talk with current and past patients. You can meet patients at the facility itself, or ask a doctor for some references to turn to. This tactic can give you valuable insight about what to expect as a patient at a particular center.

Don’t Feel Stuck

If you aren’t comfortable with your treatments or the care you are receiving from a specific place, don’t be afraid to walk out the door and find a new facility that can help you. If you are going to sign any contracts for your care, make sure that a lawyer is present and has a chance to read it before you put pen to paper. This will ensure that you don’t sign anything that will relinquish your rights as a patient in regard to the type and length of care you receive.

These tips and tricks will help you to find the perfect solution to your treatment needs, and will give you the best chance of winning your fight against cancer.

East Jefferson General Hospital includes a cancer center Metairie, LA residents can count on to help them fight the disease. To learn more, visit: http://www.ejgh.org.

A Voice Conserving Option For Advanced Laryngeal Cancer

Laryngeal cancer is the second common Head & Neck cancer in the United States, despite all the measures to curb, we in India also have high incidence because of habit of consumption of tobacco and Alcohol. The ultimate goal of every clinician treating laryngeal cancer is to remove the disease with the preservation of voice and swallowing. Early glottic and supraglottic cancers are treated by surgery or radiation therapy without affecting the phonatory function but this is difficult to achieve in larger transglottic lesions because the preferred surgical treatment for advanced laryngeal tumors remains total laryngectomy (TL), a surgical technique in which laryngeal speech is sacrificed. This is the reason majority of our Indian patients refuse treatment.

The other alternative is Radiation and chemotherapy, part of the so-called organ-sparing protocols, have also resulted in effective outcomes but 30 -40% may require salvage surgery for recurrent disease and post radiotherapy conservative procedures cannot be performed because of poor healing resulting in high fistula rate and assessment of oncological safe margins is not adequate. So these patients land in Total Laryngectomy with high postoperative complications, so primary surgery with voice conservation is preferred modality of treatment. There is a report by Hoffmann et all that for supraglottic cancers survival is poorer with Concurrent chemo radiotherapy as compared to primary surgery followed by radiotherapy.

In 1980, Pearson and colleagues described an alternative to the standard TL in patients with stage T3 glottic cancers. Following pathologic examination of an excised larynx, they noted that in certain pathology specimens, the total larynx was often not involved in the disease process. As such, these researchers discovered that the uninvolved column of endolarynx could be preserved and converted into a sphincteric tube serving as a speech valve.

Studies have shown that near-total laryngectomy (NTL) in select T3 and T4 laryngeal tumors provides a high rate of disease control comparable with that of the total laryngectomy. The NTL spares non tumor involved larynx, which is subsequently used for reconstruction. A patient who undergoes NTL speaks using an internal myomucosal shunt, which is lung powered. It does, however, require a tracheostomy for breathing.

Near-total laryngectomy (NTL) is indicated in patients with advanced (T3, T4) laryngeal cancers when the postcricoid and interarytenoid areas are free of disease and the contra lateral arytenoids is salvageable. The contraindications of this procedure are tumor in the interarytenoid, postcricoid region, and bilateral arytenoids.

A 54 years old male, also a chronic smoker, came to our hospital with the complained of change in voice for last six months and irritation in throat while having food for 3 months. Flexible direct laryngoscopy revealed ulceroproliferative lesion on the Right supraglottic area (Aryepiglottic fold + Epiglottis) with fixity of right vocal cord. Interarytenoid area and postcricoid area was free. Biopsy revealed moderately differentiated Squamous cell carcinoma. CT scan of neck revealed Right supraglottic mass with paraglottic extension with few lymph nodes at right level II, CXR did not have any evidence of disease. . Clinically it was staged as T3N1M0. The patient was discussed in the tumor board and both options of surgery and chemo radiotherapy were given to the patient. Patient chose for surgery provided he can be rehabilitated for voice production. Patient was given option of NTL/TL+ Provox voice prosthesis insertion and taken up for surgery. Intraoperative frozen section was sent from interarytenoid area for involvement which was negative, so we proceeded with NTL and bilateral level II, III, IV neck dissection. Postoperative recovery was uneventful. He was started oral feed after 10 days, he had mild aspiration which settled in few days, his voice rehabilitation was started after 2 weeks. Final Histopathology revealed T3N2M0 Squamous cell carcinoma grade II, all margins were free.

The Ultimate outcome should be oncologically safe resection margins, with good voice production for communication; this depends on in part on the surgeons skill and the extent of resection and subsequent reconstruction.

Flax Seed Does Omega-3 Reduce Cancer Risk

Primary Source of Omega-6

The primary sources of omega-6 are corn, soy, canola, safflower and sunflower oil; these oils are overabundant in the typical diet, which explains our excess omega-6 levels. Avoid or limit these oils. Omega-3, meanwhile, is typically found in flaxseed oil, walnut oil, and fish. However, flax seed oil is the best oil where Omega-3 and Omega-6 are balanced.

Benefits of Omega-3 Oil

In this Omega-3 benefits and facts section you will learn the basics about omega-3 essential fatty acids (EFA) from fish oils and their function in our bodies. Also discussed will be the affects of our western diet on omega-3 levels and the latest research on the cardiovascular, heart, and the other health benefits of omega-3 compounds. In addition there is a section on vitamin E and coenzyme Q10 antioxidants – other critical nutrients that have a synergistic role with omega-3 fatty acids. You will also find out more about Flax Seed oil and its role in our overall health.

Relationship Between Omega-3 and Cancer

Cancer is less common in communities that eat large amounts of fish, and the reason is thought to be the presence in fish of the long chain omega-3 polyunsaturates. Japanese women, for example, eat a lot of fish, and have a very low rate of breast, cancer. Men who eat fish frequently have a lower risk of prostate cancer. Stomach and intestinal cancers also appear to be less common in fish eaters. It is difficult to be specific about this though, because in such studies, there are often several factors that are different, and which could explain the lower cancer incidence.

Omega-3 Reduce Cancer Risk

Laboratory studies have provided more support to the idea that the omega-3 polyunsaturates can reduce cancer risk. For example, tests have shown that cancer-treating drugs work more effectively when there is a good level of omega-3 polyunsaturates in the diet. In summary, it can be said that taking Omega 3 and Omega 6 supplements can help curb cancer causing cells. Many doctors recommend that their patients take Flax Seed oil as it contains a balanced ration between Omega-3 and Omega-6 oil.

Omega-3 fatty acids accumulate to a considerable extent in various sites including circulating blood platelets, the heart and serum phospholipid. The accumulation of EPA and DHA in platelets is associated with decreased platelet adhesiveness and aggregation and an overall reduction in thrombogenicity. Antiatherogenic effects of omega-3 fatty acids have also been shown in animal studies.

Omega-3 For Health

Omega-3 fatty acid, may protect against the accumulation of a protein believed to be linked to Alzheimer’s disease, according to the results of a new animal study published in the March 2005 issue of The Journal of Neuroscience. This study specifically investigated one particular kind of omega 3 fatty acids – DHA Docosahexaenoic acid.

Fish Oil, Flax Seed Oil

Overall, strong evidence shows that fish oils have a strong, dose-dependent beneficial effect on triglyceride levels. There also is evidence of possible small beneficial effects on blood pressure and coronary artery restenosis after angioplasty, exercise capacity in patients with coronary atherosclerosis, and heart rate variability, particularly in patients with recent MI. Therefore, it is recommended that we have our daily does of Flax Seed oil as it contains high levels of Omega-3 oil that is essential to our health.

Fifty Four Year Old Patient Dies Of Colon Cancer After It Went Undiagnosed During 3 Colonoscopies

People with a family background of colon cancer and additionally individuals with symptoms are at increased risk of getting colon cancer. The main procedure employed by physicians to test for colon cancer if an inidividual has a family history or is complaining of a symptom, such as blood in the stool, is the colonoscopy. With this method doctors are able to see the inside of the colon and look for abnormal (and possibly cancerous) growths. In addition to testing people who are at an increased risk level, physicians also typically advocate that asymptomatic people who are 50 or older undergo routine screening in order to discover any cancer that may be developing in the colon before it reaches an advanced stage.

In case the doctor conducting the colonoscopy is unable to look at the full span of the colon it is feasible that there might be cancer present in the sections that were not examined. Among the reasons why a doctor might not finish the colonoscopy is inadequate prior preparation resulting in inadequate visualization or the presence of an obstruction which makes it impossible to pass the scope beyond the area of the obstruction. When situations like these occur the doctor should tell the patient and recommend that the individual either undergo an alternative procedure or a repeat colonoscopy. A failure to do so may lead to a missed cancer which can grow and progress to an advanced stage before it is detected.

Examine, as an example, one published lawsuit involving a 54 year old female who passed away from advanced colon cancer. The first risk factor her doctors knew about was a family history of cancer of the colon. Throughout the length of six years, physicians performed 3 colonospies on her. In that time the woman described that she observed rectal bleeding and abdominal pain frequently. Besides these two symptoms, her physicians, on at least one occasion, also noted that she had a third symptom of colon cancer – she had anemia.

In this case, the doctor who performed the colonoscopies in fact documented, with respect to two of them, that visualization was incomplete in both the ascending colon and the cecum. The physician additionally recorded that this was the situation due to the fact that there was a problem in passing the scope beyond the transverse colon. Sill, the doctor who performed the 3 colonoscopies and followed her throughout this period continued assuring her that her problems were due to hemorrhoids.

She was eventually diagnosed with colon cancer when her tumor was detected during exploratory surgery so as to uncover the cause of her problems. The cancer had grown and spread so far that the patient had to have a significant part of her intestines taken out and then had to undergo chemotherapy. Unfortunately, despite treatment she passed away from the cancer. As a result of the physician’s failure to follow up on her symptoms in light of two incomplete colonoscopies the womans family filed a lawsuit. The law firm handled the lawsuit was able to document that they acheived a settlement of $875,000 on behalf of the family.

Physicians use diagnostic tests in order to find or exclude particular diseases. For instance, the colonoscopy is employed to find or exclude colon cancer yet the result of the test is only as good as the accuracy with which the test was conducted. A colonoscopy employs a scope to see the interior of the colon to check if there are polyps or tumors in the colon

In the event that the whole colon is not visualized, as in the claim previously mentioned, a physician cannot count on it to exclude cancer. In the event that the patient does have cancer this might lead to a delay in diagnosis that allows the cancer time to grow and progress to an incurable stage. In a situation like that the doctor who counted on a partial procedure may be liable.

Cancer 7 – Sabian Astrology In 7 Words

Perhaps you have thought that your birth sign, whatsoever it may say about you, cannot really characterize you exactly? At least not with an exceptional sense that makes the whole of life seem almost poles apart from what it was before. Well then, have a glimpse at these Sabian Symbols they may make you change your mind! The Sabian approach certainly is very distinctive.

Well, you may enquire, what are these symbols? Sabian Symbols are 360 different images one for each of the 360 degrees of the zodiac that were clairvoyantly discovered by an exceptional person, Elsie Wheeler, and illuminated by a foremost astrologer, Dr Marc Edmund Jones. Each one presents a suggestion about the underlying importance of that single degree, which can get to the bottom of some very useful and provoking perceptions that you may find quite interesting.

It works even if its not your particular degree and yet a lot better if it is. Its best to allow yourself time to do it slowly, like a meditation. Let each of the short paragraphs sink in slowly and try to feel what it means, as well as using the mindor just sit with the images for a while and use your power of imagination to create some playful stories around it. (You will find your own Sabian Symbol by following the link below)

Having come to some new realizations about the essence of who you are, there is another stage you can adopt to decide to be different. You can influence a lot more of your circumstances than you usually do when you engage fully with the deepest part of your unique identity, by taking on the qualities indicated by your Sabian symbol.

Also if you are clearer about who you are, then you become a lot more certain about what you want out of life. You can set your goals according to an overall vision of the bigger picture, and that itself leads to a much greater chance of success. It helps with focus so that you keep your attention fixed on the required outcome.

Reading your own Sabian Symbol is a bit like getting a brother or sister to speak honestly about you. They know you well, with all your dark bits and your light, and although they love you, theyll tell you the hard truth! It can be difficult to hear, yet useful for those who are trying to become better people. It may be necessary to reread it a few times and think deeply about what is actually being said.

There is so much we could do with our lives! Opportunities are endless and very diverse, each day bringing little clues and teases to nudge us toward a little more unfolding of potential. Saying No to this and Yes to that surely requires us to trust our feelings and surrender to the inevitable that, come what may, we all end up being who we are: nothing more, nothing less.

Unacceptable levels of pressure of life can cause one to indulge in senseless flights of fancy, inhabiting a world of make-believe. Its not at all helpful to do this, can be quite disorienting and cause real trouble.

Nature offers unlimited scope to release each of us from psychological and physical burdens that necessarily arise out of our involvement in life. Sleep is the most obvious example, so too is daydreaming, and yet these are meant as temporary restful states rather than realistic alternatives to worldliness.

Certainly, there is a need to balance everyday strains and stresses by finding a lightness of being, which the image of two moonlit fairies suggests. It is the souls nature to fly and soar, and in moments when we can feel this, there are precious opportunities for inwardness and self-reflection; these arise as a matter of course whenever such a mood is present.

From this, one learns the ability to rise above any threats to well being that would result if one felt a sense of inescapable long term forced imprisonment in the realm of physicality and all that that entails: the compelling requirement to attend to the bodys needs and so many emotional challenges.

On the path of self-realization the sense of exaltation that comes form this lightness of being is a dynamic factor in other words, we move along more readily if such abilities are harnessed and used productively.

So the very inclination we have to space out can be productively channelled as a means to tune in and develop a transforming sensitivity. We then find that creative imagination has profound powers of healing.

Being occasionally detached from the normal heavy sense of self is truly liberating and such an ascendancy of spirit demonstrates the magical facility of selfhood.

Stimulating The Bodys Defenses To Fight Ovarian Cancer

Comediennes such as Gilda Radner and Madeline Kahn, Oscar-winning actresses like Loretta Young and Sandy Dennis, singers Laura Nyro and Dinah Shore, actor Pierce Brosnans wife Cassandra Harris, actress Jessica Tandy, former Connecticut governor Ella Grasso, and Martin Luther Kings wife Coretta Scott King all died of ovarian cancer. Its not just celebrities, politicians or movie stars, who are stricken with ovarian cancer. One in every 55 U.S. women is at risk for ovarian cancer. The American Cancer Society estimates about 22,000 new cases of ovarian cancer will be diagnosed. More than 16,000 women will die because the symptoms are often subtle, and her doctor did not recognize the symptoms soon enough. It is the leading cause of death from gynecologic malignancies, and the fifth leading cause of cancer deaths among women.

Silent and undetected, this cancer often spreads beyond the ovary or ovaries into the abdominal cavity, or by the final stage, into other body organs such as the liver or lungs. Family doctors often fail to properly diagnose The Silent Killer until it is too late. Last August, University of California Davis researchers reported 40 percent of women told their doctors about their symptoms for as long as a year before they were correctly diagnosed. A British survey discovered 75 percent of family doctors believed symptoms are only present during the advanced stages of the cancer. By the time women are diagnosed for ovarian cancer, 40 to 50 percent of the patients are in the advanced stage, where there is little hope for survival.

Less than one-half the women diagnosed with ovarian cancer will live five years. About 10 to 14 percent live beyond five years after their diagnosis. Their choices have been limited, mainly reserved to variations of chemotherapy drugs or a new way to delivery the drug. The general public is often unaware of the side effects ovarian cancer patients suffer during chemotherapy. In mid March, the U.S. Food and Drug Administration criticized the safety profile of Eli Lillys Gemzar for ovarian cancer patients, saying the 2.8 months increased survival seen in studies of patients taking the drug wasnt enough to offset the treatments increased toxicity which included anemia, neutropenia (a blood disorder) and thrombocytopenia (reduced platelets in the blood). Presently used first-line treatments for ovarian cancer patients include Cisplatin, with associated side effects such as nerve, kidney and/or ear damage, Carboplatin (side effects: nerve damage in the arms and/or legs, joint pain, and/or thrombocytopenia), Paclitaxel (neurotoxicity), or Melphalan, with side effects which include irreversible bone marrow failure, bone marrow suppression).

A woman stricken with ovarian cancer faces first surgery, then chemotherapy. Recent widespread press heralding a new development in treating ovarian cancer, intra-abdominal or intraperitoneal chemotherapy, is just that: more chemotherapy. The belly bath, as it has been nicknamed by some television reporters, it has been highly praised because the treatment can extend life by about 16 months more than regular chemotherapy. The results were first published in the prestigious New England Journal of Medicine in December 2005. Most news reports failed to mention that only 40 percent of the women treated with the belly bath were able to complete all six cycles. Why? The therapy relies upon infusions of Paclitaxel and Cisplatin (see side effects in the previous paragraph). According to Dr. Robert Edwards, research director of the Magee-Womens Gynecologic Cancer in Pittsburgh, Many women dont feel well enough to work for the duration of the intra-abdominal (therapy). Some patients, such as Cindy Pakalnis of Marshall (Pennsylvania) have called the treatments grueling.

The unsolved problem of chemotherapy is the reduction in the quality of life. While some life extension has been proven, the patients life deteriorates. Many patients struggle with balancing the loss in quality of life with the rigors of the therapy. Researchers are actively pursuing new directions that may some day provide new hope for the ovarian cancer patient. A University of Minnesota research study has suggested the use of thalidomide, which would be used in conjunction with chemotherapy, as a prospective means of increasing the likelihood of remission. Minnesota cancer researcher Dr. Levi Downs explained, It prevents the tumor from making new blood vessels. Without new blood vessels, the tumor cant sufficiently feed new cells, so the cancer cant grow. His randomized trial was small with only 65 patients (only 28 took thalidomide), and more testing will certainly be required.

New Hope for Ovarian Cancer Patients?

One promising technology that has been developed over the past decade is OvaRex MAb. It was developed by ViRexx Medical Corp., an Edmonton-based company, which trades on the American Stock Exchange (ticker symbol: REX) and on the Toronto Stock Exchange (ticker symbol: VIR). Now licensed to Unither Pharmaceuticals, a wholly owned subsidiary of United Therapeutics (NASDAQ: UTHR), OvaRex MAb is currently undergoing two identical Phase III trials at about 64 research centers across the United States. One trial has completed enrollment, according to a mid December news release issued by ViRexx Medical Corp.

We spoke with ViRexx Medical Corps Chief Executive Officer, Dr. Tyrrell who was the Dean of the Faculty of Medicine and Dentistry at the University of Alberta and the Director of the Glaxo Heritage Research Institute. OvaRex MAb is our lead candidate for the treatment of ovarian cancer, and is an intravenous infusion of a monoclonal antibody, he said. Monoclonal antibodies are a new breed of biotech drugs that are extremely specific; that is, each antibody binds to only one particular antigen. In the case of OvaRex MAb, it is a monoclonal antibody that binds specifically to the CA-125 antigen. Dr. Tyrrell added, The treatment doesnt take long, and is given every 4 weeks for the first 3 injections, and then once every 3 months until the patient relapses.

Dr. Tyrrell talked about the current Phase III studies, The trials are ongoing. All of the patients have successfully completed their surgery and front-line chemotherapy and are now in what we call the watchful waiting period. It is in this phase that we treat the patients with OvaRex MAb with the hopes of increasing the time to disease relapse. He explained the recurrence rate is very high in the stage III / IV late forms of ovarian cancer, with a time to relapse of about 10.4 months. Patients who have turned to OvaRex hope to delay that relapse. Tyrrell noted, In the original study, the average time to relapse was delayed by about 14 months. If we can achieve that difference or better in the current Phase III trials, it would be a major advance for the treatment of ovarian cancer. He expects an analysis of the current OvaRex MAb studies to be completed by the second or third quarter of 2007.

What makes OvaRex MAb different from other immunotherapeutic treatments is, instead of attacking the bodys cancerous cells directly, the monoclonal antibody targets the cancerous antigen in circulation. Some believe it helps retrain the bodys immune system to fight the ovarian cancer cells. The mechanism that reportedly has made OvaRex MAb effective is how it alerts the body to recognize and fight the CA-125.

ViRexx has addressed the tolerance problem a body suffers when it has become inflicted with a malignant tumor. The hypothesis behind the tolerance issue is that the body fails to recognize the CA-125 antigen as harmful. Introducing a foreign antibody, in this case the mouse antibody against CA125, the bodys defense systems are awakened to the ovarian cancer cells. This begins a chain reaction alerting the immune system to battle the invading antibody CA125 complex. The bodys defense systems are reprogrammed to attack the CA-125 antigen and seek to destroy it. Along with that destruction comes the attempt of the immune response to eliminate the cancerous cells from the body.

As with many pioneering scientific breakthroughs, serendipity is what lies behind the OvaRex MAb story. As one technology was being developed, another the murine monoclonal antibody treatment for ovarian cancer came about by accident. We talked to its inventor, Dr. Antoine Noujaim, about the biotech drugs roots. It came out of the imaging technology, the Professor Emeritus of the University of Alberta explained. In the early 1980s, biotech companies, such as Immunomedics and Cytomedics were researching tumors and using antibodies to image the tumors so they could be evaluated in a cancer patients body. I worked with Dr. Mike Longenecker and we established a company called Biomira (Toronto: BRA) in 1984, Dr. Noujaim recalled. We had a number of targets and then needed to make specific antibodies. Part of his effort was to target certain cancers, such as prostate, breast and ovarian cancer.

We developed antibodies against a mucin, which is really a glycopeptide, explained Dr. Noujaim. Its a peptide that has a lot of sugars on it present in the ascitis fluid from ovarian cancer patients. That is how Dr. Noujaim and his team developed the very early antibody which is now used for OvaRex MAb. We sent some of these antibodies to Professor Richard Baum in Germany for imaging of ovarian cancer patients, Noujaim remembered. Dr. Baum phoned back, after some time, and told me, The patients I was imaging here had advanced ovarian cancer and some of them seem to have done quite well after we gave them a couple of shots (of the B43.13 antibody, the clinical name for OvaRex MAb) to image the tumor. I thought he was joking with me.

This is serendipity at work as Dr. Noujaim explained to us. Richard was imaging patients that were in the last stages of the disease, he pointed out. Monoclonal antibodies can be used as diagnostic agents in oncology, when they are radiolabeled with a marker that can be imaged by external detectors. These patients had maybe four or five months to live. All of a sudden, a year later and theyre still around. Baum urged Noujaim to investigate this further. Dr. Noujaim recalls him saying, Something is happening here. Ive seen hundreds of patients, but nothing like this. From this encouragement, Noujaim began formulating the potential mechanism of how this monoclonal antibody would work. His sharp mind chased the puzzling questions raised by Dr. Baums observations.

At this point of his recollections, Noujaim got excited, Through sheer serendipity, we were using murine antibodies, not humanized antibodies. We were using foreign antibodies, a small amount of foreign antibodies. How in the world did Noujaim know to use murine (mouse) antibodies? Because that was the easiest way to do the imaging at the time, he replied. Before you make a chimeric (something derived from two different animal species) antibody, you start with a murine one. If that one works, you humanize the antibody. From this research, Noujaim founded a company called AltaRex, which was taken public in 1995. We raised about $30 million and expanded the program.

The serious effort to develop the antibodies began in 1996. Having conducted trials in Canada and Europe, it was a massive undertaking Noujaim told us. We had over 500 patients injected with the murine monoclonal antibody. He extrapolated beyond OvaRex MAb, saying, Weve proven completely the mechanism of action on this, how it works. It is so unique it may apply to all of the other antibodies we have. Noujaim believes it can apply to breast, ovarian, prostate and pancreatic cancer. Indeed, BrevaRex MAb for breast cancer and multiple myeloma patients has completed Phase 1 trials, and ProstaRex MAb for prostate cancer patients is at the pre-clinical stage.

Our studies to date may show that vaccines may slow the growth of the tumor with a very good safety profile, concluded Dr. Noujaim. Then he added something which bears investigating further, There is the very original (ovarian cancer) patient who was injected in 1987. Shes in Germany, and according to Dr. Baum she was still alive a year ago. Thats nearly nine years later! Its a matter of great pride for me that some people who received OvaRex MAb are alive today, he said.

While the company has licensed, under a royalty agreement, the OvaRex MAb technology to United Therapeutics, through that companys subsidiary, Unither Pharmaceuticals, ViRexx has retained rights to most member nations of the European Union and certain other countries. Key ones include France, the United Kingdom and the Benelux countries. ViRexx has also established strategic relationships with Domp Farmaceutici, Medison Pharma, Ltd. and Genesis Pharma S.A. for certain European and Middle-East Countries.

What Are The Symptoms Of Colon Cancer

Colon cancer symptoms are not apparent all times, in particular in the initial stages of development of cancer cells. Learning briefly about what is colon cancer helps you in better understanding of colon cancer symptoms.

Colon forms major part of the digestive system of the body and plays an important role in absorption of essential nutrition and water, thus facilitating good health. Further, colon also assists in removing the toxic substance and body waste through stool or as stool. Major portion of large intestine is comprised of Colon. Development of cancerous cells or malignant tumors in the colon is referred as colon cancer. Let us see the colon cancer symptoms in detail.

As stated earlier, colon cancer symptoms are not apparent in the initial stages and can be detected only when it is progressed to advanced stage. However, with deep and intense screening, it is possible to detect the signs of colon cancer.

Symptoms of colon cancer can be classified into two types namely local symptoms and systemic symptoms. Former is associated with digestive system and the later affects the entire body. Some of the symptoms of colon cancer found to be sings of other health conditions and illnesses, in particular the local symptoms. Proper diagnosis helps in detecting the cancerous growth.

Bloody stool: Blood discharge in the stool is the most common and apparent symptom of Colon cancer. However, bloody discharge is associated with some other health conditions. Moreover, the stool gets discharged in red color like bloody discharge when you eat beetroot or watermelon. Eventually, the condition can be diagnosed by Fecal occult blood test.

Constipation: It is rare sign of colon cancer and it is associated with many digestive illnesses. Constipation at frequent intervals and chronic constipation might be dangerous, because such condition is usually developed when the growth of cancer cells obstruct discharging stool.

Diarrhea / watery stool: Since the colon is obstructed by cancer tissues, it becomes difficult in discharging normal stool and lead towards watery stool, ribbon like stools and chronic diarrhea.

Unusual bowel movements: Irritable and unusual bowel movement with swollen abdomen is one of the obvious symptoms of colon cancer, where there will be a sensation of fullness of stomach, even when it is empty. And it is caused due to growth of cancer cells in colon and digestive system.

Fatigue: Fatigue and general weakness is a common problem experienced by almost everyone. But, continuous fatigue and weariness for several days is the apparent symptom of a severe health condition. Colon cancer symptoms include fatigue associated with anemic condition which is caused due to loss of blood in stool and diarrhea.

Pain in the abdomen: Difficult in discharging stool, bowel movements, fullness of stomach, blocked digestive system due to tumor cells, etc lead towards abdominal pain.

Other colon cancer symptoms include the following:
Unexpected and accidental weight loss without involvement of diet or any other weight loss plans
Loss of energy and extreme weariness
Anaemic condition or iron deficiency with much low counts of red blood cells
Loss of appetite
Jaundice

Since most of the colon cancer symptoms can be realized only in the advanced stage, where the tumors affect the entire digestive system, it is good to get appropriate diagnosis with several medical examinations, when one or more signs mentioned above are experienced. Earlier detection of colon cancer can prevent the development of cancer cells and enhance the survival rate.

Is Colon Cancer Caused By Constipation Or Emotional Trauma

We know that colon cancer is the second leading cause of deaths in the United States. In 1999, of all the cancer deaths, 16% of them were colon cancer. But where did the other cancers originate – lung, prostate, breast, lymph, pancreatic, stomach? Did they also start in the colon where the colon toxin simply migrated to these regions?

Many colon cancers develop slowly over time and can be attributed to constipation. And, constipation can be related, in most cases, to past emotional trauma or experiences. Constipation that occurs over a long period of time creates toxins that continually migrate into your blood and into your body cells and tissues.

It is difficult to trace where cancers originate. Medical professionals, when treating a patient, are not really concerned with where the cancer or illness came from. They are more interested in how to treat the disease or the symptoms with drugs or surgery.

Many doctors do not go looking for the cause of your problem. They don’t have the time for this research. In fact, they normally will not tell you what you need to do to prevent your illness. Sometimes the reason they will not tell you is they just do not know.

Its becoming more a nutritionist’s or naturopathic doctor’s job to tell you what foods and supplements you need to eat to prevent and to overcome specific illnesses and what to eat to eliminate or stop constipation.

People are dying at all ages with a variety of diseases. Why is it that so many people are dying of heart diseases, blood diseases, cancers, autoimmune diseases and the list goes on. It has been know for a longtime why diseases occur and what you can do to prevent it.

These death producing illnesses are a result of how and what we eat, the type of water we drink, and the air pollution we breathe. But perhaps one of the most important causes of diseases that are seldom discussed comes from the thoughts we think.

What is it that causes our behavior? A behavior that is harmful to others or ourselves in ways that affects our health and life. Why do people smoke when they know it causes Cancer? Why do people drink coffee when they know caffeine affects their adrenal gland, which eventually leads to exhaustion? Why is it that people eat sugar or white floor products when they know it has untold health effects beyond diabetes?

The answer is simple, but many people are not willing to accept this idea. All illness originates from repressed traumatic memories resulting from early life trauma.

Dr Arthur Janov explains this clearly in his book, 1996, Why You Get Sick How You Get Well.

“Over the last thirty years I have learned a great deal about humans and what drives them. As trite as it may seem, what I have found is a single yet complex emotion called love. Not the romantic love of novels, but a fundamental love – the love of a parent for a child. When a child lacks love and nurturing, no matter how that lack is manifest, it creates pain, and if this pain is not “felt” or integrated into the system, it will in turn cause physical and emotional illness in later life.”

Changing ones thoughts, behavior, and life style is difficult to do and requires psychological help. Not too many people are willing to do this unless they are force to by life situations. Unfortunately, this is what is necessary to reduce or eliminate illness. This is what is necessary to bring on a feeling of well-being way into your old age – at 80, at 90, at 100, and well beyond that.

How many people are willing to devote the time and money to start eating the right foods and change their behavior and lifestyle? This is the first step in reducing or eliminating constipation or any other illness and for dealing with past emotional trauma.